Results 51 to 60 of about 683,530 (338)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Adjustment of Coatings Morphology and Particle Distribution of Layered Silicates by Freeze‐Drying for Improved Gas Barriers

Advanced Engineering Materials, EarlyView.
Freeze‐drying of layered silicate is the key to get coatings with superior gas barrier. Freeze‐drying of layered silicates modified with dodecylamine (DDA) is a highly effective technique for the preparation of barrier pigments that significantly mitigate the permeation of oxygen, water vapor, and hydrogen through polymer films containing these ...
Joshua Lommes, Moritz Bätcher, Andrea Deißenberger, Volkmar Stenzel, Andreas Hartwig   +4 more
wiley   +1 more source

Numerical Simulation of Air Flow through Cracks of Structures in Nuclear Power Plant

南方能源建设
[Objective] Human health is protected by nuclear plant ventilation systems providing the dynamic air shields by maintaining differential pressure between contamination zone and other areas and the radioactive contamination leaking is prevented. Under the
Guangyu ZHU, wei JIA, Lu CHEN, Bin JIA, Xinli GAO, Kunpeng WANG   +5 more
doaj   +1 more source

Obtaining stable strains of microorganisms with increased production of hydrolytic enzymes by methods of induced mutagenesis and their characteristics [PDF]

BIO Web of Conferences
In order to increase the level of production of hydrolytic enzymes of natural producers and select highly productive microorganisms, a study was carried out on the effectiveness of various approaches to induced mutagenesis, as well as a comparative study
Valiullin L. R., Mukhammadiev Rin S., Mukhammadiev Rish S., Saifullin A. S., Samsonov A. I., Gumerov V. G., Yarullin A. I., Baryshev M. G.   +7 more
doaj   +1 more source

Trace Nickel Activated Biphasic Core‐CuOii/Shell‐CuOi Secondary Microspheres Enable Room Temperature Parts‐Per‐Trillion‐Level NO2 Detection

Advanced Engineering Materials, EarlyView.
An idea of designing novel sensors is proposed by creating appropriate Schottky barriers and vacancies between isomorphous Core‐CuOii/ Shell‐CuOi secondary microspheres and enhancing catalytic and spill‐over effects, and electronegativity via spontaneous biphasic separation, self‐assembly, and trace‐Ni‐doping.
Bala Ismail Adamu, Peipei Chen, Shafia Mukhtar Ibrahim, Mukhtar Lawan Adam, Attia Falak, Mokhotjwa Simon Dhlamini, Hanfu Wang, Lingxiang Jiang, Weiguo Chu   +8 more
wiley   +1 more source

Use of HRM-Analysis of the Melting Curves Obtained after Amplification of VNTR-Loci for Identification and Differentiation of Brucella Strains

Проблемы особо опасных инфекций
The aim of the present study was to evaluate the effectiveness of analysis of the high resolution melting curves obtained after amplification of VNTR loci for the identification and differentiation of Brucella strains.Materials and methods. 16 strains of
E. A. Anisimova, D. A. Mirgazov, E. A. Dodonova, I. A. Elizarova, E. V. Pankova, K. A. Osyanin   +5 more
doaj   +1 more source

Optimal KI Prophylactic Dose Determination for Thyroid Radiation Protection After a Single Administration in Adult Rats

Dose-Response, 2017
A dose–response study was performed in adult rats to select an optimal stable potassium iodide (KI) dose which could be implemented in repeated prophylaxis, in case of prolonged exposure to radioactive iodine.
Guillaume Phan, François Rebière, David Suhard, Alexandre Legrand, Floriane Carpentier, Thibaud Sontag, Maâmar Souidi, Jean-René Jourdain, Michelle Agarande, Valérie Renaud-Salis   +9 more
doaj   +1 more source

Gas chromatography–mass spectrometry determination of deltamethrin in food

Учёные записки Казанского университета: Серия Естественные науки, 2021
The article presents the results of the determination of the synthetic pyrethroid deltamethrin in raw food and various food products by gas chromatography with mass spectrometric detection (GC–MS).
I.M. Fitsev, E.R. Rakhmetova, A.G. Mukhammetshina, K.E. Burkin, O.V. Shlyamina   +4 more
doaj   +1 more source

Design and Prototyping of Topology‐Optimized, Additively Manufactured Lightweight Components for Space Robotic Systems: A Case Study

Advanced Engineering Materials, EarlyView.
The results demonstrate a simulation‐driven workflow that applies LSB topology optimization with additive manufacturing constraints to mission‐specific load cases, integrating European Cooperation for Space Standardization compliant verification and manufacturability to develop structurally efficient rover suspension components.
Stelios K. Georgantzinos, Grigorios Kostopoulos, Eleni Papadopoulou, Stefanos Voulgaris, Alexandra Tseni, Panteleimon Bakalis, Maria N. Gkara, Chara Ch. Mitropoulou, Georgios Kazakis, Alin Munteanu, Jeremi Gancet, Nikos D. Lagaros   +11 more
wiley   +1 more source