Results 51 to 60 of about 693,912 (345)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2011 The expected increase of total integrated luminosity by a factor ten at the HL-LHC compared to the design goals for LHC essentially eliminates the safety factor for radiation hardness realized at the current cold amplifiers of the ATLAS Hadronic End-cap ...
Nagel, Martin
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Numerical Simulation of Air Flow through Cracks of Structures in Nuclear Power Plant
南方能源建设[Objective] Human health is protected by nuclear plant ventilation systems providing the dynamic air shields by maintaining differential pressure between contamination zone and other areas and the radioactive contamination leaking is prevented. Under the
Guangyu ZHU +5 more
doaj +1 more source
Status and Assessment Method of Nuclear Safety Analysis Software in China
Frontiers in Energy Research, 2021 In recent years, China’s nuclear power industry has enjoyed a good momentum of development, and related companies have also developed many nuclear analysis software applications.
Xinli Gao +12 more
doaj +1 more source
, 1990 The following subject areas are covered: (1) impact of frequency change of user and spacecraft antenna gain and size; (2) basic personal terminal antennas (impact of 20/30 GHz frequency separation; parametric studies - gain, size, weight; gain and figure
Cramer, Paul, Jamnejad, Vahraz
core +1 more source
Phase 1b/2a trial of the superoxide dismutase mimetic GC4419 to reduce chemoradiotherapy-induced oral mucositis in patients with oral cavity or oropharyngeal carcinoma [PDF]
, 2018 PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral ...
Adkins, Douglas +13 more
core +2 more sources
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Проблемы особо опасных инфекцийThe aim of the present study was to evaluate the effectiveness of analysis of the high resolution melting curves obtained after amplification of VNTR loci for the identification and differentiation of Brucella strains.Materials and methods. 16 strains of
E. A. Anisimova +5 more
doaj +1 more source