Results 41 to 50 of about 634,083 (315)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Thoracic spinal cord compression due to xtramedullary haemopoiesis in a patient with beta-thalassemia: complete clinical regression with radiation therapy alone

, 2014
Spinal cord compression due to Extramedullary   Haemopoesis in beta-thalassemia is extremely rare. Controversies are there between the two modalities of treatment surgery vs radiation therapy.
Chattopadhyay, Subrata; Department of Radiation Oncology, North Bengal Medical College& Hospital, Siliguri, Chatterjee, Koushik; Department of Radiation Oncology, IPGMER & SSKM Hospital, Kolkata, Saha, Aramita; Department of Radiation Oncology, IPGMER & SSKM Hospital, Kolkata, Azam, Mohammad; Department of Radiation Oncology, Medical College, Kolkata   +3 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Attitude Survey on Radiation

, 2020
In Japan, cancer treatment is expected to continue increasing as the number of elderly people increases. Since surgery is a heavy physical burden for the elderly, pain after operation and exhaustion of physical fitness are major problems in quality of ...
鍛治, 聡, ハタ, ユカコ, 宮崎, 滋夫, カジ, アキラ, Miyazaki, Shigeo, 296, Morita, Yuki, 574, 575, Kurashima, Yukiko, 576, 577, 578, 579, ニシ, マサト, Nishide, Yuri, クラシマ, ユキコ, 西, 正人, サカイ, リョウスケ, 西出, 侑里, 倉島, 由紀子, Yamashita, Osamu, Hata, Yukako, Sakai, Ryosuke, 山下, 修, ミヤザキ, シゲオ, 森田, 有紀, 580, 581, 9000250758071, 畑　, 友佳子, 582, 583, 584, 585, 坂井, 良輔, Nishi, Masato, 586, 587, 588, 589, ヤマシタ, オサム, ニシデ, ユリ, モリタ, ユキ, Kaji, Akira, 87   +45 more
core   +1 more source

Disparities in the Utilization of Radiation Therapy for Prostate Cancer in the United States: A Comprehensive Review

, 2022
Purpose: Major advances in radiation therapy (RT) for prostate cancer increase the importance of equity in the use of RT. We sought to assess the evolution of RT utilization disparities in prostate cancer to inform clinicians and health care ...
McClelland, Shearwood, III., Deville, Curtiland, Jr., Gardner, Ulysses, Jr.   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Rare Case of a Well-Differentiated Paratesticular Sarcoma of the Spermatic Cord in a 60-Year-Old Patient

Case Reports in Urology, 2017
Introduction. Liposarcomas are tumors that occur mostly in the retroperitoneum. Of all liposarcomas only 3 to 7% are found in the paratesticular region. The spermatic cord is the main site of origin in these cases.
Marwen Benna, Semia Zarraâ, Asma Belaïd, Aziz Cherif, Lotfi Kochbati, Mohammed Chebil, Farouk Benna   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quantifying the Carbon Footprint of External Beam Radiation Therapy—A Narrative Review

Journal of Medical Radiation Sciences
The health care sector contributes significant amounts of greenhouse gases (GHGs) to the global climate change issue. However, little remains known about the specific contribution of radiation therapy even though there are methods/tools to quantify its ...
Karen Mukasa Kyeyune, Michelle Leech
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source