Results 51 to 60 of about 634,083 (315)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A dosimetric analysis of the aeroformTM tissue expander in radiation therapy

, 2014
Purpose: The aim of this study is to evaluate the effects of the metallic reservoir and the use of gas within the Aeroform™ tissue expander with respect to the radiation dose distribution.Methods: Dosimetric effects of using a metallic reservoir within a
Melven, Leon; Department of Radiation Therapy, Radiation Oncology Victoria, Epping, Australia., Tran, Tai; Department of Physics, Radiation Oncology Victoria, Epping, Australia., Farrow, Hamish; Plastic and Reconstructive Surgery Unit, Austin Hospital, Heidelberg, Australia., Baker, Caroline; Department of Surgery, Victorian Breast and Oncology Care, East Melbourne, Australia., Ding, Wei; Department of Physics, Radiation Oncology Victoria, Epping, Australia., Subramanian, Brindha; Department of Physics, Radiation Oncology Victoria, Epping, Australia., Chao, Michael; Department of Oncology, Radiation Oncology Victoria, Ringwood, Australia.   +6 more
core   +1 more source

Photofrin II as an efficient radiosensitizing agent in an experimental tumor [PDF]

, 2001
Background and Objective: The use of ionizing irradiation as radiation therapy (RT) for tumor treatment represents a well-established method. The use of photodynamic therapy (PDT), especially with Photofrin II, for tumor treatment is also known. Chemical
Corti, L., Schaffer, Pamela Manuela, Hofstetter, Alfons, Jori, G., Dühmke, Eckhart, Sotti, G., Schaffer, Moshe   +6 more
core   +1 more source

Radiation-Induced Lymphopenia Risks of Photon Versus Proton Therapy for Esophageal Cancer Patients

, 2021
Purpose: To assess possible differences in radiation-induced lymphocyte depletion for esophageal cancer patients being treated with the following 3 treatment modalities: intensity-modulated radiation therapy (IMRT), passive scattering proton therapy ...
Mohan, Radhe, Ebrahimi, Saba, Ellsworth, Susannah G., Lin, Steven H., Cao, Wenhua, Lim, Gino, Liu, Amy, Grassberger, Clemens   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Modeling and analysis of radiation therapy system with respiratory compensation using Uppaal

, 2011
The goal of radiation therapy is to give as much dose as possible to the exact target location and minimizing any dose to a normal tissue. Advances of Cyber-physical control systems allow planning and provide very accurate treatments.
Kevin Lee, Danny Hughes, Tomas Krilavicius, Kaiyu Wan, Lee, K., Ka Lok Man, Man, K. L., Hughes, D., Krilavicius, T., Wang, K.   +9 more
core   +1 more source

Abscopal effect after palliative five-fraction radiation therapy on bone and lymph node metastases from luminal B breast cancer: a case report and clinical implications for palliative radiation therapy [PDF]

, 2021
The abscopal effect is a phenomenon in which radiation therapy results in the regression of metastatic lesions at a distance from the irradiated lesions. Here, we have described a 37-year-old woman with advanced luminal B breast cancer who presented with
김태형, 장지석
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

3D Monte Carlo radiation transfer modelling of photodynamic therapy

, 2015
We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.The effects of ageing and skin type on Photodynamic Therapy (PDT) for ...
Wood, Kenneth, Valentine, Ronan M., Christison, C., C. Louise Campbell, Campbell, C. Louise, Kenneth Wood, Brown, C Tom A, Moseley, H., Moseley, Harry, C. Tom A. Brown, Campbell, Catherine Louise, Harry Moseley, Wood, Kenny, Brown, C. Tom A, Craig Christison, Ronan M. Valentine, Christison, Craig, Valentine, Ronan Martin   +17 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source