Results 81 to 90 of about 6,788,828 (423)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current Trends and Controversies

Technology in Cancer Research and Treatment, 2018
Hepatocellular carcinoma is the fourth leading cause of cancer-related death worldwide. Depending on the extent of disease and competing comorbidities for mortality, multiple liver-directed therapy options exist for the treatment of hepatocellular ...
S. Schaub, P. Hartvigson, M. Lock, M. Høyer, T. Brunner, H. Cardenes, L. Dawson, Edward Y. Kim, N. Mayr, S. Lo, S. Apisarnthanarax   +10 more
semanticscholar   +1 more source

Clinical results of proton beam therapy for twenty older patients with esophageal cancer

Radiology and Oncology, 2015
Background. In an aging society, increasing number of older patients are diagnosed with esophageal cancer. The purpose of this study was to assess the clinical efficacy and safety of proton beam therapy for older patients with esophageal cancer.
Ono Takashi, Nakamura Tatsuya, Azami Yusuke, Yamaguchi Hisashi, Hayashi Yuichiro, Suzuki Motohisa, Hatayama Yoshiomi, Tsukiyama Iwao, Hareyama Masato, Kikuchi Yasuhiro, Nemoto Kenji   +10 more
doaj   +1 more source

Selection Strategy of Jaw Tracking in VMAT Planning for Lung SBRT

Frontiers in Oncology, 2022
PurposeThis study aimed to investigate the dosimetric effect and delivery reliability of jaw tracking (JT) with increasing planning target volume (PTV) for lung stereotactic body radiation therapy (SBRT) plans.
Wuji Sun, Yinghua Shi, Yu Li, Chao Ge, Xu Yang, Wenming Xia, Kunzhi Chen, Libo Wang, Lihua Dong, Lihua Dong, Lihua Dong, Huidong Wang, Huidong Wang   +12 more
doaj   +1 more source

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

Predicting Cancer Treatments Induced Cardiotoxicity of Breast Cancer Patients [PDF]

arXiv, 2022
Cardiotoxicity induced by the breast cancer treatments (i.e., chemotherapy, targeted therapy and radiation therapy) is a significant problem for breast cancer patients. The cardiotoxicity risk for breast cancer patients receiving different treatments remains unclear.
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Intensity-modulated radiation therapy: a review with a physics perspective

Radiation Oncology Journal, 2018
Intensity-modulated radiation therapy (IMRT) has been considered the most successful development in radiation oncology since the introduction of computed tomography into treatment planning that enabled three-dimensional conformal radiotherapy in 1980s ...
B. Cho
semanticscholar   +1 more source

Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck

Frontiers in Oncology, 2021
Abundance and signaling of the epidermal growth factor receptor (EGFR) and programmed cell death protein ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) are not only genetically determined but are also subject to the traits of the tumor
Sebastian Zahnreich, Senayit Gebrekidan, Gabriele Multhoff, Gabriele Multhoff, Peter Vaupel, Heinz Schmidberger, Arnulf Mayer   +6 more
doaj   +1 more source

Radiation therapy and serum salivary amylase in head and neck cancer [PDF]

, 2017
Radiation therapy (RT) is a valid treatment option for head and neck cancer (HNC). The risk of RT-induced toxicities is significant, especially due to extended treatment fields.
DE FELICE, Francesca, Marampon, Francesco, Musella, Angela, Musio, Daniela, Tombolini, Mario, Tombolini, Vincenzo   +5 more
core   +2 more sources