Results 31 to 40 of about 132,052 (260)

Patient-Reported Tolerance of Magnetic Resonance-Guided Radiation Therapy

Frontiers in Oncology, 2020
PurposeMagnetic resonance-guided radiation therapy (MRgRT) has been incorporated into a growing number of clinical practices world-wide, however, there is limited data on patient experiences with MRgRT.
Mutlay Sayan, Ilkay Serbez, Bilgehan Teymur, Gokhan Gur, Teuta Zoto Mustafayev, Gorkem Gungor, Banu Atalar, Enis Ozyar   +7 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Enhancing radiation tolerance by controlling defect mobility and migration pathways in multicomponent single-phase alloys

Nature Communications, 2016
Radiation tolerance is a property determined both by materials structure and defect dynamics. Here authors demonstrate enhancement of radiation tolerance at elevated temperatures in equiatomic single-phase concentrated solid solution alloys and propose ...
Chenyang Lu, Liangliang Niu, Nanjun Chen, Ke Jin, Taini Yang, Pengyuan Xiu, Yanwen Zhang, Fei Gao, Hongbin Bei, Shi Shi, Mo-Rigen He, Ian M. Robertson, William J. Weber, Lumin Wang   +13 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mechanical Tensile Response of Ni–Graphene Nanocomposites in Hydrogen-Irradiation-Coupled Environments Using Molecular Dynamics Simulations

Nanomaterials
In Gen-IV nuclear reactors, structural materials must endure unprecedented levels of neutron irradiation and hydrogen exposure, posing significant challenges for traditional Ni-based alloys.
Tonghe Liu, Xiaoting Yuan, Hai Huang
doaj   +1 more source

Selection of radiation tolerant commercial greases for high-radiation areas at CERN: Methodology and applications

Nuclear Materials and Energy, 2021
At the European Laboratory for Particle Physics (CERN), commercial greases and oils are extensively used to lubricate moving devices operating in high-radiation areas, absorbing doses up to the MGy range. Due to their sensitivity to radiation, lubricants
Matteo Ferrari, Dominika Senajova, Keith Kershaw, Antonio Perillo Marcone, Marco Calviani   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluating the Radiation Tolerance of a Robotic Finger [PDF]

, 2018
In 2024, The Large Hadron Collider (LHC) at CERN will be upgraded to increase its luminosity by a factor of 10 (HL-LHC). The ATLAS inner detector (ITk) will be upgraded at the same time. It has suffered the most radiation damage, as it is the section closest to the beamline, and the particle collisions.
Richard French, Alice Cryer, Gabriel Kapellmann-Zafra, Hector Marin-Reyes   +3 more
openaire   +3 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source