Results 71 to 80 of about 248,973 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Precipitation-hardening stainless steels: Potential use radiation shielding materials

, 2022
In this study, it was focused on the research of new materials with high attenuation efficiency that can be used as radiation shielding material due to the incapability of conventional materials.
Han, Ibrahim, Alim, Bunyamin, Ozpolat, Ozgur Firat, Arslan, Ibrahim, Sakar, Erdem, Demir, Lutfu, Singh, V. P.   +6 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Efficiency on the Use of Radiation and Corn Yield under Three Densities of Sowing [PDF]

, 2016
Aiming to evaluate sowing densities and efficiency of radiation use, six corn genotypes, three from open pollination (“Amarillo Almoloya,” “Cacahuacintle,” and “Jiquipilco”) and three hybrids (“Z-60,” “Condor,” and “H-50”), were sown at densities of 6.9,
A. Morales-Ruiz, M. D. Mariezcurrena-Berasaín, O. Franco-Mora, J. M. Loeza-Corte, E. Díaz-López, G. Estrada-Campuzano, E. J. Morales-Rosales   +6 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Comprehensive analysis on investigating water-saving potentials of irrigated cotton in semi-arid area in China

Agricultural Water Management
Deficit irrigation is a common strategy to reduce water use and improve the sustainability of cotton production. However, the effects of water deficits on crop productivity and quality are subject to genotype by management by environmental interactions ...
Xiaoyu Zhi, Barbara George-Jaeggli, Yingchun Han, Qiaomin Chen, Shijie Zhang, Lu Feng, Yaping Lei, Xiaofei Li, Guoping Wang, Zhanbiao Wang, Shiwu Xiong, Minghua Xin, Yahui Jiao, Yunzhen Ma, Yabing Li, Beifang Yang   +15 more
doaj   +1 more source

Radiation-use efficiency among grain sorghum cultivars and plant densities

, 1993
Radiation-use efficiency (RUE, g MJ-1) has often been used in many crop model equations to estimate total biomass and yield based on cumulative absorbed photosynthetically active radiation. Management practice effects on radiation-use efficiency have not
Rosenthal, W.D., Wade, L.J., Gerik, T.J.
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source