Results 51 to 60 of about 32,925 (248)

Mitotic dynamics of the nuclear lamina behind the scenes of chromosome separation

Communications Biology
The regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation.
Julien Picotto, Pascale Bertrand, Gaëlle Pennarun   +2 more
doaj   +1 more source

A comparative analysis of the NaI detector response function using GAMOS and FLUKA Monte Carlo simulations

Nuclear Analysis
This work aims to study the response function of a 2″×2″ NaI(Tl) scintillation detector using Monte Carlo simulations. A precise mathematical model of the NaI(Tl) scintillator was developed using both FLUKA and GAMOS Monte Carlo simulation software.
A. Arectout, H. Boukhal, E. Chakir, M. Jarmouni, M. Assalmi, T. El Ghalbzouri, O.E. Belhaj, Mohamed Drissi El-Bouzaidi, A. Nouayti, I. Zidouh, H. El Yaakoubi   +10 more
doaj   +1 more source

Positron-based attenuation correction for Positron Emission Tomography data using MCNP6 code

Journal of Radiation Research and Applied Sciences, 2016
This paper presents the Monte Carlo simulation of the attenuation correction for Positron Emission Tomography (PET) data using MCNP6 code. Two attenuation correction maps have been generated, one for correcting the attenuation effect in a homogeneous ...
M. Saeed, T. El Khoukhi, Y. Boulaich, E. Chakir, M. Maged, H. Boukhal, T. El Bardouni   +6 more
doaj   +1 more source

Influence of Individual Radiosensitivity on the Hormesis Phenomenon: Toward a Mechanistic Explanation Based on the Nucleoshuttling of ATM Protein

Dose-Response, 2020
Hormesis is a low-dose phenomenon that has been reported to occur, to different extents, in animals, plants, and microorganisms. However, a review of the literature shows that only a few reports describe it in humans.
Clément Devic, Mélanie L. Ferlazzo, Elise Berthel, Nicolas Foray   +3 more
doaj   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Investigation of photon interaction parameters in Human Body Tissues using GAMOS, FLUKA, and XCOM Studies

Nuclear Analysis
This study aims to evaluate different photon interaction parameters of human body organs at nine photon energies (0.021 keV–1.25 MeV) using GAMOS and FLUKA Monte Carlo codes.
A. Arectout, H. Boukhal, M. Jarmouni, K. Laazouzi, M. Assalmi, A. Nouayti, M. Hadouachi, H. El Yaakoubi, E. Chakir   +8 more
doaj   +1 more source

UV-B Radiations and Secondary Metabolites

Turkish Journal of Agriculture: Food Science and Technology, 2020
Ultraviolet-B (UV-B: 280 to 320 nm) radiations have appeared to be detrimental to plants, due to their damaging effects on proteins, lipids, membranes and DNA. UV-B radiations are a significant regulator of plants’ secondary metabolites.
İlkay Yavaş, Aydın Ünay, Shafaqat Ali, Zohaib Abbas   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source