Results 301 to 310 of about 4,184,658 (417)

PCET-mediated deconstructive cross-coupling of aliphatic alcohols. [PDF]

Chem Sci
Patehebieke Y, Charaf R, Pal KB, Baamonde BM, Brnovic A, Hammarström L, Wallentin CJ.   +6 more
europepmc   +1 more source

ON THE NATURE OF FREE RADICALS DETECTED BY PARAMAGNETIC RESONANCE IN BIOLOGICAL SUBSTANCES

, 1958
Ichiro Miyagawa, Walter Gordy, Norimitsu Watabe, Karl M. Wilbur   +3 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

A 22-year experience of surgical management of anorectal melanoma: risk factors for recurrence and death. [PDF]

Int J Colorectal Dis
Sassun R, Larson DW, Sileo A, Ng JC, Ferrari D, McKenna NP, Perry WRG.   +6 more
europepmc   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Enantioselective acyl-trifluoromethylation of olefins by bulky thiazolium carbene catalysis. [PDF]

Nat Commun
Jana S, Wodrich MD, Cramer N.
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A Novel Definition and Grading Diagnostic Criteria for Tumour-Type-Specific Comprehensive Cachexia Risk. [PDF]

J Cachexia Sarcopenia Muscle
Hu C, Cong M, Song C, Xu H, Guo Z, Zhou F, Zhou L, Weng M, Rao B, Deng L, Yu K, Chen Y, Wang Z, Ruan G, Yang M, Liu C, Cui J, Li W, Wang K, Li Z, Liu M, Li T, Chen J, von Haehling S, Barazzoni R, Shi H.   +25 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Development and validation of the competing risk nomogram and risk classification system for predicting cancer-specific mortality in patients with cervical adenosquamous carcinoma treated via radical hysterectomy. [PDF]

Biomol Biomed
Yi J, Chen J, Cao X, Pi L, Zhou C, Liu Z, Mu H.   +6 more
europepmc   +1 more source