Results 91 to 100 of about 207,495 (287)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Optimization of wavy fin‐and‐elliptical tube heat exchanger using CFD, multi‐objective genetic algorithm and radical basis function

Energy Science & Engineering, 2021
This article presents an accurate and efficient optimization method for heat exchanger. The structure of the original heat exchanger was optimized by combining LHS sampling, CFD simulation, radical basis function, and multi‐objective optimization.
Chao Yu, Xiangyao Xue, Kui Shi, Renhao Wang, Lei Zhang, Mingzhen Shao   +5 more
doaj   +1 more source

Spectroscopic and Computational Studies of Matrix-Isolated iso-CXBr3 (X=F,Cl,Br): Structure, Properties, and Photochemistry of Substituted Iso-Tribromomethanes [PDF]

, 2012
Iso-polyhalomethanes are important reactive intermediates in the condensed and gas-phase chemistry of halomethanes. Building upon our recent study of iso-bromoform, in this work the substituted iso-tribromomethanes (iso-CXBr3; X = F, Cl, Br) were ...
Esselman, Brian J., George, Lisa, Kalume, Aimable, McMahon, Robert J., Reid, Scott   +4 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

BLUF Domain Function Does Not Require a Metastable Radical Intermediate State [PDF]

, 2014
BLUF (blue light using flavin) domain proteins are an important family of blue light-sensing proteins which control a wide variety of functions in cells. The primary light-activated step in the BLUF domain is not yet established. A number of experimental
Agnieszka Gil, Allison Haigney, Anderson S., Andras Lukacs, Bonetti C., Bonetti C., Braatsch S., Brust R., Brust R., Domratcheva T., Dragnea V., Duvanel G., Fiedler B., Gauden M., Gauden M., Gauden M., Gomelsky M., Greetham G. M., Gregory M. Greetham, Grinstead J. S., Haigney A., Haigney A., Hsiao Y.-W., Ishikita H., Jung A., Kennis J. T. M., Khrenova M. G., Khrenova M. G., Kiri Addison, Kondo M., Kottke T., Laan W., Laan W., Losi A., Losi A., Lukacs A., Lukacs A., Lukacs A., Marcus R. A., Masuda S., Masuda S., Masuda S., Masuda S., Masuda S., Mathes T., Mathes T., Mathes T., Meier K., Meier K., Michael Towrie, Moglich A., Mussi M. A., Okajima K., Peter J. Tonge, Pimenta F. M., Reece S. Y., Reece S. Y., Richard Brust, Rosspeintner A., Rosspeintner A., Ruiz-Gonzalez R., Sadeghian K., Sadeghian K., Sadeghian K., Sato Y., Sergey P. Laptenok, Seyedsayamdost M. R., Stelling A. L., Stephen R. Meech, Stierl M., Tommos C., Udvarhelyi A., Udvarhelyi A., Unno M., Unno M., Van der Horst M. A., Walden S. E., Wolf M. M. N., Zhao R.-K.   +78 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Magnetically Stimulated Myogenesis Recruits a CRY2-TRPC1 Photosensitive Signaling Axis

Cells
The cryptochromes are flavoproteins that either individually or synergistically respond to light and magnetic field directionality as well as are implicated in circadian rhythm entrainment and development. Single brief exposures (10 min) to low energy (1.
Jan Nikolas Iversen, Yee Kit Tai, Kwan Yu Wu, Craig Jun Kit Wong, Hao Yang Lim, Alfredo Franco-Obregón   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock.

PLoS Biology, 2009
Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown.
Taishi Yoshii, Margaret Ahmad, Charlotte Helfrich-Förster   +2 more
doaj   +1 more source

Photoactivated biological processes as quantum measurements. [PDF]

, 2015
We outline a framework for describing photoactivated biological reactions as generalized quantum measurements of external fields, for which the biological system takes on the role of a quantum meter.
Imamoglu, A, Whaley, KB
core   +1 more source