Results 91 to 100 of about 1,224,999 (294)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The ‘Autonomous Nationalists’: new developments and contradictions in the German neo-Nazi movement [PDF]

open access: yes, 2013
This article examines the action repertoires, symbolism and political ideology of the ‘Autonomous Nationalists’ (Autonome Nationalisten in German) that have emerged as a sub-cultural youth trend within the German extreme right.
Schlembach, Raphael
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Immigrant, Nationalist and Proud: A Twitter Analysis of Indian Diaspora Supporters for Brexit and Trump

open access: yesMedia and Communication, 2019
The Brexit referendum to leave the EU and Trump’s success in the US general election in 2016 sparked new waves of discussion on nativism, nationalism, and the far right.
Eviane Cheng Leidig
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The Radical Right versus the Media: from Media Critique to Claims of (Mis)Representation

open access: yesPolitics and Governance, 2019
Criticizing mainstream media for their ‘lies’ or ‘fake news’ has become a common political practice on the radical right. Further empirical research is needed to better understand the intricacies of these attacks on media, in particular for the way they ...
Louise Knops, Benjamin De Cleen
doaj   +1 more source

Hungary, Poland and Slovakia show the risks associated with mainstream parties co-opting the platforms of the radical right [PDF]

open access: yes, 2015
The rise of the radical right has presented a challenge to mainstream parties in a number of European countries. As Bartek Pytlas writes, one of the strategies mainstream parties have adopted in several cases has been to co-opt the platforms of radical ...
Pytlas, Bartek
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Affective Polarization Among Radical‐Right Supporters: Dislike Differentiation and Democratic Support

open access: yesPolitics and Governance
Partisan affective polarization describes the extent to which different partisans like or dislike each other. In Europe, affective dislike is strongest towards the radical-right, as mainstream voters tend to hold particularly negative affect towards ...
Jochem Vanagt   +3 more
doaj   +1 more source

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