pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Tesla's multi-frequency wireless radio controlled vessel
A review of the Tesla’s contribution to dual-band wireless radio controlled vessel is presented. The intention of this paper is to describe multi-frequency remote controlled vessel using two transmitters and which operate a distant receiver which ...
Budimir, D. +3 more
core +1 more source
On the character and distribution of lower-frequency radio emissions at Saturn and their relationship to substorm-like events [PDF]
With the arrival of the Cassini spacecraft at Saturn in July 2004, there have been quasi-continuous observations of Saturn kilometric radiation (SKR) emissions.
L. Lamy +24 more
core +1 more source
Radio-Frequency Association of Efimov Trimers [PDF]
Few-Body Problem Seemingly simple, quantum mechanical few-body systems are notoriously difficult to describe. Efimov trimers, three-body bound states with interactions tuned to be in close vicinity of the formation of two-body bound states, are the most tractable of these systems, with relevance, for example, in nuclear physics ...
Lompe, T. +5 more
openaire +5 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An optical fibre-based frequency dissemination network for Australia
An optical-fibre network is being planned for distribution of optical and microwave reference frequencies in Australia. This network would connect a number of research facilities and the National Measurement Institute (NMI), allowing long-range ...
Luiten, A. +9 more
core +1 more source
Dual Polarized Reconfigurable Frequency Selective Surfaces [PDF]
Novel band-stop active frequency selective surfaces (FSS) capable of modifying their response for different polarizations are proposed. Geometries based on full rings, and split rings are employed.
Sanz-Izquierdo, B., Parker, E.A.
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Beam downtilt reconfigurable linear antenna array for 5G/6G macro base stations
In this letter, a beam downtilt reconfigurable linear antenna array is presented for the demand of the electrical downtilt of 5G/6G macro base station antennas.
Li Chen +4 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source

