Results 61 to 70 of about 143,695 (268)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Topological transition of Pancharatnam–Berry phase in a nonlocal twisted bilayer metasurface

Scientific Reports
The Pancharatnam-Berry (PB) phase principle has been extensively utilized in the design of polarization-dependent, ultrathin, phase-gradient metasurfaces, where the PB phase shift is determined by twice the change in orientation angle of individual ...
Yongqing Huang, Yachao Liu, Mingwei Wang, Xiandi Chen, Haoliang Han, Aofei Yu, Guo Ping Wang   +6 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

YOLO Network-Based Extraction of Target Geometry From Time-Frequency Representation

IEEE Access
In response to challenges in target geometric parameter extraction from radar echoes, an improved YOLOv8 neural network model is proposed in this paper to recognize target types and extract geometric parameters of targets from time-frequency ...
Jingyuan Han, Kunyi Guo, Xinqing Sheng
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

SAF-PUF: A Strong PUF with Zero-BER, ML-Resilience and Dynamic Key Concealment Enabled by RRAM Stuck-at-Faults

Applied Sciences
Targeting resource-constrained Internet of Things (IoT) devices, this paper proposes Stuck-at-Fault Physical Unclonable Function (SAF-PUF), a lightweight Resistive Random-Access Memory (RRAM)-based PUF that exploits the intrinsic addresses of ...
Qianwu Zhang, Bingyang Zheng, Lin-Sheng Wu, Xin Zhao   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Radiation behaviour of mm‐wave on‐wafer probes in H‐band and the influence on antenna measurements

Electronics Letters
This letter presents a comprehensive analysis of the radiation behaviour exhibited by nine distinct on‐wafer radio‐freqeuncy (RF) probes used for device characterization in the mm‐wave bands of integrated circuits and antennas.
Joachim Hebeler, Thomas Zwick, Akanksha Bhutani   +2 more
doaj   +1 more source