Results 41 to 50 of about 450,454 (338)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Zero-Point cooling and low heating of trapped 111Cd+ ions

, 2004
We report on ground state laser cooling of single 111Cd+ ions confined in radio-frequency (Paul) traps. Heating rates of trapped ion motion are measured for two different trapping geometries and electrode materials, where no effort was made to shield the
Blinov, B. B., Brickman, K-A., Deslauriers, L., Haljan, P. C., Lee, P. J., Madsen, M. J., Monroe, C.   +6 more
core   +1 more source

Radio frequency heating coils for shock wave experiments [PDF]

, 1997
Radio-frequency eddy current heating of metallic samples in shock wave, ultrasonic and diamond anvil apparatus provides a methodology for obtaining hot samples or hot metallic gaskets (containing a sample) and yet not heating the entire target ...
Ahrens, Thomas J., Chen, George Q.
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Limitation of the modulation method to smooth wire guide roughness

, 2010
It was recently demonstrated that wire guide roughness can be suppressed by modulating the wire currents so that the atoms experience a time-averaged potential without roughness. We theoretically study the limitations of this technique. At low modulation
C. L. Garrido Alzar, E. Landau, I. Bouchoule, J.-B. Trebbia, R. Folman   +4 more
core   +1 more source

Minority and mode conversion heating in (3He)-H JET plasma [PDF]

, 2012
Radio frequency (RF) heating experiments have recently been conducted in JET (He-3)-H plasmas. This type of plasmas will be used in ITER's non-activated operation phase.
Beaumont, P., Blackman, T., Brennan, D., Brett, A., Calabro, G., Cecconello, M., Coffey, I., Coyne, A., Crombe, K., Czarnecka, A., Felton, R., Frigione, D., Gatu Johnson, M., Giroud, C., Gorini, G., Hellesen, C., Hellsten, T, Jacquet, P., JET EFDA Contributors,, Johnson, T J, Kazakov, Yevgen, Kiptily, V., Knipe, S., Krasilnikov, A., Lennholm, M., Lerche, E, Lin, Y., Maslov, M., Mayoral, M.-L., Monakhov, I., Noble, C., Nocente, M., Ongena, J, Pangioni, L., Proverbio, I., Sozzi, C., Stamp, M., Studholme, W., Tardocchi, M., Van Eester, D, Vdovin, V., Versloot, T.W., Whitehurst, A., Wooldridge, E., Zoita, V.   +44 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Electromagnetic absorption mechanisms in metal nanospheres: Bulk and surface effects in radiofrequency-terahertz heating of nanoparticles [PDF]

, 2011
The following article appeared in Journal of Applied Physics 109.12 (2011): 124306 and may be found at http://scitation.aip.org/content/aip/journal/jap/109/12/10.1063/1.3600222We report on the absorption of electromagnetic radiation by metallic ...
Bohen C. F., Curley S. A., G. W. Hanson, Mathews J., R. C. Monreal, S. P. Apell, Stratton J. A.   +6 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Kinetic simulation of the sheath dynamics in the intermediate radio-frequency regime

, 2013
The dynamics of temporally modulated plasma boundary sheaths is studied in the intermediate radio frequency regime where the applied radio frequency and the ion plasma frequency are comparable.
Brinkmann, R. P., Derzsi, A., Donkó, Z., Elgendy, A. T., Eremin, D., Korolov, I., Mussenbrock, T., Schulze, J., Shihab, M.   +8 more
core   +1 more source