Results 61 to 70 of about 3,863,163 (394)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2018 The mitigation of non-line-of-sight propagation conditions is one of main challenges in wireless signal–based indoor localization. When radio frequency identification localization technology is applied in applications, the received signal strength ...
Jie Wu, Minghua Zhu, Bo Xiao, Wei He
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
IEEE Journal of Indoor and Seamless Positioning and NavigationIn this article, we present a unique comparative analysis, and evaluation of vision-, radio-, and audio-based localization algorithms. We create the first baseline for the aforementioned sensors using the recently published Lund University Vision, Radio,
Ilayda Yaman +9 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Adaptive Density Graph-Based Manifold Alignment for Fingerprinting Indoor Localization
IEEE Access, 2020 The received signal strength (RSS) fingerprint-based indoor localization has been considered as a promising solution, due to its relatively high localization accuracy and its ease of use in widespread Wireless Local Area Network (WLAN) infrastructure.
Shibao Li +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2017 This article addresses the problem of indoor localization with an augmented ultra-high-frequency radio frequency identification system. In the infrastructure of augmented ultra-high-frequency radio frequency identification system, a tag-like component ...
Jing Wang, Miodrag Bolić
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source