Results 131 to 140 of about 591,717 (256)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Solution Synthesis of Actinide Chalcogenide and Oxychalcogenide Nanoparticles

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
We report the synthesis of UOS, UOSe, and US2 nanoparticles under colloidal conditions. The magnetic properties were measured of all three materials and compared to prior studies of UO2 nanoparticles. Nanoparticle phases were determined using powder diffraction, and size by transmission electron microscopy.
Cheyenne Orozco, Orlando C. Stewart Jr., Nicole Vanagas, Greg Morrison, Hans‐Conrad zur Loye, Hope E. Smith, Karah Knope, Sarah L. Stoll   +7 more
wiley   +2 more sources

Quantitative Cherenkov‐excited fluorescence emission dosimetry for HDR Co‐60 brachytherapy: Calibration and planar validation against TPS

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Accurate dose verification in High‐Dose‐Rate (HDR) brachytherapy presents a significant challenge due to steep dose gradients and the absence of beam collimation. Conventional quality assurance (QA) methods typically rely on point detectors or film‐based techniques, which lack the capability to provide real‐time, full‐field ...
Yagiz Yedekci, Mehmet Fazıl Enkavi, Ferah Yildiz   +2 more
wiley   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, Volume 38, Issue 52, 16 September 2026.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

An Optimized Electrochemical Biosensor for Real‐Time Monitoring of Lactate in Human Saliva With Enhanced Sensitivity, Stability, and Reproducibility

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
Rational multilayer surface engineering combines Prussian Blue, lactate oxidase, BSA, and a zwitterionic coating to regulate substrate transport and minimize biofouling. The optimized architecture extends the dynamic range to physiologically relevant salivary lactate concentrations, enabling reliable electrochemical sensing directly in untreated human ...
Gylxhane Kastrati, Leif Riemenschneider, Torsten Sterzenbach, Yutong Wu, Carballo Torres Dimas, Luis Antonio Panes‐Ruiz, Abdallh Herbawe, Michael Geiger‐Hoffmann, Kristin Hille, Stephanie Klinghammer, Christian Hannig, Gianaurelio Cuniberti   +11 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Influence of the external and internal radioactive contamination of the body and the clothes on the results of the thyroidal ¹³¹I measurements conducted in Belarus after the Chernobyl accident. Part 1: Estimation of the external and internal radioactive contamination. [PDF]

Radiat Environ Biophys, 2019
Drozdovitch V, Khrouch V, Minenko V, Konstantinov Y, Khrutchinsky A, Kutsen S, Kukhta T, Shinkarev S, Gavrilin Y, Luckyanov N, Voillequé P, Bouville A.   +11 more
europepmc   +1 more source

Impact Assessment and Sustainable Remediation of Heavy Metal and Radioactive Contamination in Aquatic Systems: A Review. [PDF]

Water Environ Res
Joshi HK, Punetha G, Pandey D.
europepmc   +1 more source