Results 101 to 110 of about 168,622 (140)

X‐Ray Absorption Studies of Local Structure of Dilute Ionic Species in Molten Salts

Chemistry–Methods, EarlyView.
This article reviews the state of the art in the use of X‐ray absorption spectroscopy methods, both experimental and theoretical, for understanding the structure of dopant metal ions in molten salts. Recent strategies, including molecular dynamics simulations and neural network–assisted analysis of X‐ ray absorption spectroscopy as well as chemometrics
Kaifeng Zheng, Nirmalendu Patra, Nicholas Marcella, Alexander S. Ivanov, James F. Wishart, Alejandro R. Ballesteros, Ruchi Gakhar, Sheng Dai, Santanu Roy, Vyacheslav Bryantsev, Simerjeet K. Gill, Anatoly I. Frenkel   +11 more
wiley   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Evaluation of Potential Effects of CYP3A Inhibition and CYP3A Induction on the Pharmacokinetics of Fruquintinib in Healthy Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez, Zhao Yang, William R Schelman, Xiaofei Zhou, Neeraj Gupta, Caly Chien   +5 more
wiley   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source

Tackling Environmental Impact: A New Support Tool for Sustainable Healthcare Waste Management

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study proposes a novel framework integrating Environmental Risk Assessment (ERA) and Material Flow Analysis (MFA) within the Deming Cycle framework to address this gap. While valuable tools, ERA and MFA offer limited perspectives on environmental impact when used alone.
Carlotta D'Alessandro, Katarzyna Szopik‐Depczyńska, Raffaella Taddeo, Katarzyna Cheba, Giuseppe Ioppolo   +4 more
wiley   +1 more source

Synthesis of Lithium Manganese Oxide and Ti‐Substituted LMO Sorbents for Lithium Extraction in a Spray‐Drying Process

ChemSusChem, EarlyView.
Herein, a novel synthetic, scalable approach brines is presented to produce Li1.6Mn1.6O4 (lithium manganese oxides [LMO]) with high phase purity for direct lithium extraction applications from Li‐rich geothermal. Compared to conventional hydrothermal approaches, the LMO materials prepared herein display lower manganese leaching rates, higher extraction
Laura Herrmann, Nicole Bohn, Alisa Pfau, Thomas Kölbel, Helmut Ehrenberg, Joachim R. Binder, Fabian Jeschull   +6 more
wiley   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

Gas migration at the granite–bentonite interface under semirigid boundary conditions in the context of high‐level radioactive waste disposal

Deep Underground Science and Engineering, EarlyView.
A series of water infiltration tests and gas permeability tests were conducted on granite and granite–bentonite samples. According to the results, the interfaces between granite and bentonite and the damaged granite were considered to be the preferentcial pathway for gas migration.
Jiangfeng Liu, Zhipeng Wang, Jingna Guo, Andrey Jivkov, Majid Sedighi, Jianfu Shao   +5 more
wiley   +1 more source