Results 111 to 120 of about 398,650 (328)

From Design to Outcome: The Role of Bi‐ and Multifunctional Ligands in Modern Therapeutics

open access: yesAdvanced Therapeutics, EarlyView.
This review highlights the innovative use of bi‐ and multifunctional ligands for precision therapeutics. From strategic linker design to bioorthogonal conjugation and nanoscaffold integration, these approaches enable precise targeting, high‐resolution receptor mapping, and enhanced drug delivery.
Célia Bouacha   +2 more
wiley   +1 more source

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

open access: yesAdvanced Science, EarlyView.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang   +17 more
wiley   +1 more source

Growth Responses of Holcus lanatus L. (Velvet Grass) in Soils Contaminated with Cesium or Strontium

open access: yesSoil Systems
Radiocesium (r-Cs) and radiostrontium (r-Sr) released from nuclear accidents (e.g., Chornobyl, Fukushima) and routine operations (reactors, reprocessing) pose environmental and health concerns.
Bayezid M. Khan   +3 more
doaj   +1 more source

Background gamma radiation mapping in forest ecosystem of Bangladesh: A study on the radioactivity distribution in the national reserve forest of Gazipur

open access: yesRadiation Protection and Environment, 2017
Natural and artificial radioactivity appears to be different in different geological regions. Moreover, the radionuclides may migrate to the deeper region of the earth after deposition, and the depth profile of a radionuclide reveals information on the ...
Sheikh Shariful Islam   +9 more
doaj   +1 more source

THE SPECIFIC RADIOACTIVITY OF URANIUM.1 [PDF]

open access: green, 1907
Herbert N. McCoy, William H. Ross
openalex   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism

open access: yesAdvanced Science, EarlyView.
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding   +19 more
wiley   +1 more source

Modelling of radiocesium transfer in the lichen-reindeer/caribou-wolf food chain

open access: yesRangifer, 1990
The environmental contaminate radiocesium (cesium-137) has been shown to be of value as a marker in food selection and intake studies. Its greatest potential value as a food marker is in the subarctic/arctic regions, particularly in the lichen to ...
D. F. Holleman   +2 more
doaj   +1 more source

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