Results 71 to 80 of about 495,743 (373)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Retention of 2011 Fukushima Dai-ichi NPP accident-derived 137Cs in the northern North Pacific–Bering Sea

Scientific Reports
Tracing soluble radionuclides is critical for understanding the mechanisms underlying the transport of soluble materials in marine environments. In the present study, we investigated the surface distribution of the concentrations (activities) of 134Cs ...
Mutsuo Inoue, Hayata Mitsunushi, Daichi Koshiishi, Yasunori Hamajima, Seiya Nagao, Daiki Nomura, Yuichiro Kumamoto   +6 more
doaj   +1 more source

Identification of hazards for water environment in the Upper Silesian Coal Basin caused by the discharge of salt mine water containing particularly harmful substances and radionuclides

Journal of Sustainable Mining, 2015
The Upper Silesian urban-industrial agglomeration is one of the most industrialized areas in Europe. The intense industrialization should be attributed mostly to the presence of coal and other minerals deposits and its extraction.
Jan Bondaruk, Ewa Janson, Małgorzata Wysocka, Stanisław Chałupnik   +3 more
doaj   +1 more source

Maintenance and degradation of proteins in intact and severed axons: Implications for the mechanism of long-term survival of anucleate crayfish axons [PDF]

, 1995
Protein maintenance and degradation are examined in the severed distal (anucleate) portions of crayfish medial giant axons (MGAs), which remain viable for over 7 months following axotomy.
Bittner, George D., Storm, Elaine E., Tanner, Sandra L.   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Handbook explaining the fundamentals of nuclear and atomic physics [PDF]

, 1969
Indoctrination document presents nuclear, reactor, and atomic physics in an easy, straightforward manner. The entire subject of nuclear physics including atomic structure ionization, isotopes, radioactivity, and reactor dynamics is ...
Hanlen, D. F., Morse, W. J.
core   +1 more source

Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Labelled Amino Acids into Isolated Mitochondria from Neurospora crassa [PDF]

, 1969
Radioactive amino acids were incorporated into isolated mitochondria from Neurospora crassa. Then the mitochondrial ribosomes were isolated and submitted to density gradient centrifugation. A preferential labelling of polysomes was observed.
Dingman C. W., Dingman C. W., Kuntzel H., Kuntzel H., Luck D. J. L., Neupert W., Noll H., Peacock A. C., Rifkin M. R.   +8 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Transformation of different reaches of the Niida River (Japan) after extreme flood

Revista de Geomorfologie, 2017
Extreme floods can have different effects on the river bottom relief depending on several factors. The geomorphological impact of the extreme flood occurring in the Niida River basin (Fukushima prefecture, Honshu inland, Japan) on the channels and river ...
Valentin GOLOSOV, Dmitry BOTAVIN, Alexei KONOPLEV, Yoshifumi WAKIYAMA   +3 more
doaj   +1 more source