Results 71 to 80 of about 168,622 (140)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Quantifying Imperfect Cognition Via Achieved Information Gain

Annalen der Physik, EarlyView.
Cognition, the processing of information in the form of inference, communication, and memorization, is the central activity of any intelligence. To quantify imperfect cognition, the concept of achieved information gain (AIG) is introduced. AIG can be derived axiomatically, allows cognitive fidelity and efficiency to be defined mathematically, and ...
Torsten Enßlin
wiley   +1 more source

Surface Characterization of Scintillator‐Adsorbed Polyethylene Terephthalate Film and Its Use for Detecting α$$ \upalpha $$‐ and β$$ \upbeta $$‐Particles

Journal of Applied Polymer Science, EarlyView.
Thermal transfer using the high‐temperature crimping method led to the bonding of cellulose fibers and a scintillator to the film surface. β‐Particles of tritiated water were detected by immersing the scintillator‐adsorbed film. Scintillation images of the scintillator‐adsorbed film were obtained by irradiating β‐particles from 90Sr/90Y and α‐particles
Hirokazu Miyoshi, Ayumi Fukuhara, Mami Nakamura   +2 more
wiley   +1 more source

Showcasing the Structure and Properties of Lanthanide‐Doped BaTiO3

Advanced Physics Research, EarlyView.
Understanding the defect chemistry of Ln‐doped BTO, as well as the distribution of Ln ions inside the BTO host, is a challenge in the study of functional perovskite oxides. It provides important insights into the future development of Ln‐doped BTO materials, particularly in the context of low‐carbon transition strategies and renewable technologies that
Takeshi Nakagawa, Melita Menelaou, Martina Vrankić   +2 more
wiley   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This work presents the pioneering development of an aptamer‐based electrochemical biosensor for real‐time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH ...
Reza Didarian, Saharnaz Bargh, Almina Gülerman, Veli Cengiz Özalp, Özcan Erel, Nimet Yildirim‐Tirgil   +5 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Sodium Manganese Hexacyanoferrate: Characterization as Sodium‐Ion Battery Cathode Material, Full Cell Cycling with Hard Carbon and Post‐Mortem Analyses

Batteries &Supercaps, EarlyView.
Sodium manganese hexacyanoferrate (NaMnHCF) is a promising cathode for sodium‐ion batteries due to its LFP‐like voltage profile and cost‐effective composition. This study examines its cycling performance with hard carbon anodes, highlighting Na+ inventory loss as a key degradation factor.
Sebastian Büchele, Valeriu Mereacre, Nicole Bohn, Pirmin Stüble, Xuebin Wu, Noah Keim, Ruochen Xu, Holger Geßwein, Wenzhe Sun, Grigor Vrhovac, Michael Pordzik, Thomas Bergfeldt, Sylvio Indris, Werner Bauer, Helmut Ehrenberg, Joachim R. Binder   +15 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source