Results 71 to 80 of about 408,195 (330)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Implementation of real-time source apportionment approaches using the ACSM–Xact–Aethalometer (AXA) setup with SoFi RT: the Athens case study [PDF]

Atmospheric Measurement Techniques
Air pollution, particularly from particulate matter (PM), poses serious public health and environmental risks, especially in urban areas. To address this, accurate source apportionment (SA) of PM is essential for effective air quality management ...
M. I. Manousakas, M. I. Manousakas, O. Zografou, F. Canonaco, E. Diapouli, S. Papagiannis, M. Gini, V. Vasilatou, A. Tobler, S. Vratolis, J. G. Slowik, K. R. Daellenbach, A. S. H. Prevot, K. Eleftheriadis   +13 more
doaj   +1 more source

Bedrock radioactivity influences the rate and spectrum of mutation

eLife, 2020
All organisms on Earth are exposed to low doses of natural radioactivity but some habitats are more radioactive than others. Yet, documenting the influence of natural radioactivity on the evolution of biodiversity is challenging.
Nathanaëlle Saclier, Patrick Chardon, Florian Malard, Lara Konecny-Dupré, David Eme, Arnaud Bellec, Vincent Breton, Laurent Duret, Tristan Lefebure, Christophe J Douady   +9 more
doaj   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Apollo 17 mission Report. Supplement 6: Calibration results for gamma ray spectrometer sodium iodide crystal [PDF]

A major difficulty in medium energy gamma-ray remote sensing spectroscopy and astronomy measurements was the high rate of unwanted background resulting from the following major sources: (1) prompt secondary gamma-rays produced by cosmic-ray interactions ...
Dyer, C., Trombka, J. I.
core   +1 more source

Theory of the two-proton radioactivity in the continuum shell model

, 2005
We develop the microscopic description of the two-nucleon radioactivity in the framework of the Shell Model Embedded in the Continuum. This approach is applied for the description of spontaneous two-proton radioactivity in $^{45}$Fe, $^{48}$Ni and $^{54}$
Barker, Barker, Bartz, Bartz, Bennaceur, Bennaceur, Bennaceur, Berggren, Berggren, Blank, Blomqvist, Brown, Brown, Case, Cole, Daehnick, Delves, Drożdż, Efimov, Eppel, Fano, Feshbach, Feshbach, Garrido, Garrido, Giovinazzo, Goldansky, Gomez del Campo, Grigorenko, Grigorenko, Grigorenko, Grigorenko, Grigorenko, Halderson, Honma, Id Betan, Id Betan, Id Betan, J. Okołowicz, J. Rotureau, Kahana, Lind, Luo, M. Płoszajczak, Mahaux, Michel, Michel, Michel, Michel, Michel, Michel, Michel, Migdal, Nielsen, Nummela, Nunes, Okołowicz, Ormand, Pfützner, Philpott, Poves, Raynal, Rotter, Rotureau, Shyam, Watson, Wendler, Wildenthal   +67 more
core   +3 more sources

Early Detection of Chemotherapy‐Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (2H) Metabolic Imaging: in Vitro and in Vivo Assessments

Advanced Science, EarlyView.
This study presents the first application of deuterium metabolic imaging (DMI) for assessing therapeutic response in bladder cancer. Employing [2,3,4,6,6′‐2H5]‐D‐glucose, DMI successfully identified chemotherapy‐induced suppression of glycolysis both in vitro and in vivo.
Lingmin Kong, Ganghan Yang, Bei Weng, Zhihua Wen, Joshua D. Kaggie, Qian Cai, Qian Wan, Cuien Zheng, Feng Du, Ye Li, Xin Liu, Ferdia A. Gallagher, Yan Guo, Shi‐Ting Feng, Chao Zou, Huanjun Wang   +15 more
wiley   +1 more source

An update on soil gas harvesting technique as a non-depleting source of 222Rn for a large volume calibration chamber for long-term exposure experiments

Radiation Medicine and Protection
Objective: To demonstrate the versatility of the natural soil gas harvesting technique, coupled with a semi-dynamic injection algorithm, as an efficient and reliable source for continuous 222Rn delivery to a large-volume calibration chamber across ...
A.P. Vijith, N. Karunakara
doaj   +1 more source

The retention of S35-labelled bovine serum albumin on normal and immunized rabbit liver tissue [PDF]

, 1957
The S35-label of S35-BSA was detected in the liver tissue of rabbits to the extent of 0.02 per cent (10 µg or sime 1014 molecules) of the injected material at 140 days after injection.
Campbell, Dan H., Garvey, Justine S.
core   +2 more sources