Results 211 to 220 of about 11,524,538 (332)

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

Precision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge   +9 more
wiley   +1 more source

A Phase 1 Microtracer Study Evaluating the Mass Balance, Excretion, and Pharmacokinetics of Osivelotor in Healthy Participants. [PDF]

Clin Transl Sci
Zimmerman EI, Callegari E, Sharma R, Adenola A, Volpe J, Seetharaman K, Zhang C, Duchin K, Walker GS.   +8 more
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Human Radiolabeled Mass Balance Studies Supporting New Drugs Approved by FDA Between 2019 and 2023. [PDF]

Clin Transl Sci
Ramamoorthy A, Chen A, Chow ECY, Guinn D, Iyer A, Pahwa S, Ren Y, Shukla C, Doddapaneni S, Danielsen ZY.   +9 more
europepmc   +1 more source

Absorption and translocation of 14C‐propiconazole associated with two adjuvants in young coffee plants

Pest Management Science, EarlyView.
Experimental workflow evaluating 14C‐propiconazole absorption and translocation in Coffea arabica with two biodegradable adjuvants, quantified at six post‐application time points using radioscanner and liquid scintillation spectrometry. Abstract BACKGROUND This study evaluated the absorption, translocation and distribution of 14C‐propiconazole applied ...
Valéria de Souza Ivo, Emerson Leite, José Mak, Valdemar Luiz Tornisielo, Kassio Ferreira Mendes   +4 more
wiley   +1 more source

Highly sensitive positron imaging reveals short-term food distribution patterns in ant groups. [PDF]

Sci Rep
Suzui N, Yamaguchi M, Higashino S, Yin YG, Miyoshi Y, Suwa R, Tsuji K, Kawachi N.   +7 more
europepmc   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Toxicokinetic and Partial Mass Balance Assessment of ¹⁴C-Alpha Olefins in Rats. [PDF]

J Xenobiot
Shi Q, Dunn J, Carrillo JC, Penman MG, Powrie RH, Haines C, Shen H, Tian Y, Jia S, Hubert F, Boogaard PJ.   +10 more
europepmc   +1 more source

Scaling turbulence drives the general circulation

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The NOAA Gulfstream SP4, which deployed the GPS dropsondes over the NE Pacific Ocean as part of the Winter Storms Project during the January–March periods of 2004, 2005 and 2006. Abstract Statistical multifractal analysis of airborne and dropsonde observations is used to show that persistence of velocity after molecular collisions breaks the continuous
Adrian F. Tuck
wiley   +1 more source

Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy. [PDF]

J Pharmacokinet Pharmacodyn
Port RE, Boswell CA, Ogasawara A, Gill H, Marik J, Tarantal AF, Berg E, Williams SP, Ferl GZ.   +8 more
europepmc   +1 more source