Results 11 to 20 of about 7,835 (150)

¹⁸F-Radiopharmaceutical Diversification Enabled by Deaminative Cross-Electrophile Couplings. [PDF]

Angew Chem Int Ed Engl
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Ogilvy IF, Ford J, Ortalli S, Renders E, Hayes TR, Liu S, Mortiers I, Nikolopoulou A, Sorlin AM, Trabanco AA, Tredwell M, Buijnsters PJJA, Salter R, Gouverneur V.   +13 more
europepmc   +2 more sources

One-Pot Base-Free Suzuki-Miyaura [¹¹C]Methylation: Kinetic and Mechanistic Insights. [PDF]

Chemistry
A base‐free Suzuki–Miyaura [11C]methylation is achieved in a one‐pot process with [11C]CH3I on moderate yields. Electronic effects enable transmetallation without boronate activation, while kinetics and DFT show oxidative addition (heterolytic) as the rate‐limiting step.
Moreno O, Azzeggarh I, Holland JP, Windhorst AD, Llop J.   +4 more
europepmc   +2 more sources

Fully Automated GMP-Compliant Synthesis of [¹⁸F]FE-PE2I

Pharmaceuticals, 2021
In the struggle to understand and accurately diagnose Parkinson′s disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ...
Klas Bratteby, Charlotte Lund Denholt, Szabolcs Lehel, Ida Nymann Petersen, Jacob Madsen, Maria Erlandsson, Tomas Ohlsson, Matthias Manfred Herth, Nic Gillings   +8 more
doaj   +1 more source

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

EJNMMI Radiopharmacy and Chemistry, 2023
Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development.
Jean DaSilva, Clemens Decristoforo, Robert H. Mach, Guy Bormans, Giuseppe Carlucci, Mohammed Al-Qahtani, Adriano Duatti, Antony D. Gee, Wiktor Szymanski, Sietske Rubow, Jeroen Hendrikx, Xing Yang, Hongmei Jia, Junbo Zhang, Peter Caravan, Hua Yang, Jan Rijn Zeevaart, Miguel Avila Rodriquez, Ralph Santos Oliveira, Marcela Zubillaga, Tamer Sakr, Sarah Spreckelmeyer   +21 more
doaj   +1 more source

Preparation, Optimisation, and In Vitro Evaluation of [¹⁸F]AlF-NOTA-Pamidronic Acid for Bone Imaging PET

Molecules, 2022
[18F]sodium fluoride ([18F]NaF) is recognised to be superior to [99mTc]-methyl diphosphate ([99mTc]Tc-MDP) and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in bone imaging. However, there is concern that [18F]NaF uptake is not cancer-specific, leading to a
Hishar Hassan, Muhamad Faiz Othman, Hairil Rashmizal Abdul Razak, Zainul Amiruddin Zakaria, Fathinul Fikri Ahmad Saad, Mohd Azuraidi Osman, Loh Hui Yi, Zarif Ashhar, Jaleezah Idris, Mohd Hamdi Noor Abdul Hamid, Zaitulhusna M. Safee   +10 more
doaj   +1 more source

Reactive Palladium–Ligand Complexes for ¹¹C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry

Pharmaceuticals, 2023
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmaceuticals at
Kenneth Dahl, Anton Lindberg, Neil Vasdev, Magnus Schou   +3 more
doaj   +1 more source

Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges

Applied Sciences, 2012
Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodologies
Carmen Wängler, Alexey Kostikov, Jun Zhu, Joshua Chin, Björn Wängler, Ralf Schirrmacher   +5 more
doaj   +1 more source

The Metamorphosis of Radionuclide Production and Development at Paul Scherrer Institute

CHIMIA, 2020
Radionuclide production and development has a long history at the Paul Scherrer Institute (PSI) and dates back to the founding times of its forerunner institutions: the Federal Institute for Reactor Research and the Swiss Institute for Nuclear Research ...
Pascal V. Grundler, Robert Eichler, Zeynep Talip, P. August Schubiger, Roger Schibli, Nicholas P. van der Meulen   +5 more
doaj   +1 more source

Evaluation of [⁶⁴Cu]Cu-NOTA-PEG₇-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [¹¹¹In]In-DOTA-PEG₁₁-BisPy-Tz

Molecules, 2021
Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie, Jesper T. Jørgensen, Vladimir Shalgunov, Georgios Kougioumtzoglou, Troels Elmer Jeppesen, Andreas Kjaer, Matthias M. Herth   +6 more
doaj   +1 more source

Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic

Angewandte Chemie, EarlyView.
Synopsis. The [68Ga]GaIII‐TREN‐CAM radiochelate selectively accumulates in Gram‐negative sites of infection and noninvasively monitors treatment response a siderophore antibiotic. ABSTRACT Positron emission tomography (PET) is an emerging tool under clinical investigation for the detection of bacterial infections.
M. Andrey Joaqui‐Joaqui, Phuong Nguyen Tran, Axia Marlin, Fiona Armstrong‐Pavlik, Minhua Cao, Valérie C. Pierre, Eszter Boros   +6 more
wiley   +2 more sources