Results 21 to 30 of about 10,349 (201)
Radiochemistry and drug synthesis ‘in a flash [PDF]
, 2019 Conventional methods for radiolabelling proteins are time consuming and difficult to automate. In this article, Jason P. Holland discusses how combining photochemistry with radiochemistry enables development of radiolabelled proteins far more quickly and
Holland, Jason P; https://orcid.org/
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Molecules, 2021 Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie +6 more
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Novel radiochemistry for positron emission tomography imaging
, 2020 This thesis describes the development of novel radiochemistry using fluorine-18 and its subsequent application in conducting Positron Emission Tomography (PET) imaging in vivo. Publication of this work: J. Am. Chem. Soc.
Tack, Osman
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Scientific Reports, 2017 In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to ...
Andrew V. Mossine +5 more
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Novel Receptor Tyrosine Kinase Pathway Inhibitors for Targeted Radionuclide Therapy of Glioblastoma
Pharmaceuticals, 2021 Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is common in GB, which subsequently leads to the activation of many ...
Julie Bolcaen +5 more
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The Metamorphosis of Radionuclide Production and Development at Paul Scherrer Institute
CHIMIA, 2020 Radionuclide production and development has a long history at the Paul Scherrer Institute (PSI) and dates back to the founding times of its forerunner institutions: the Federal Institute for Reactor Research and the Swiss Institute for Nuclear Research ...
Pascal V. Grundler +5 more
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Angewandte Chemie, EarlyView.This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong +2 more
wiley +2 more sources
Pharmaceutics, 2021 Radiolabeled peptides possessing an Arg-Gly-Asp (RGD) motif are widely used radiopharmaceuticals for PET imaging of tumor angiogenesis due to their high affinity and selectivity to αvβ3 integrin.
Barbara Gyuricza +6 more
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The Rise of Synaptic Density PET Imaging
Molecules, 2020 Many neurological disorders are related to synaptic loss or pathologies. Before the boom of positrons emission tomography (PET) imaging of synapses, synaptic quantification could only be achieved in vitro on brain samples after autopsy or surgical ...
Guillaume Becker +3 more
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Radiotracers for Imaging of Fibrosis: Advances during the Last Two Decades and Future Directions
Pharmaceuticals, 2023 Fibrosis accompanies various pathologies, and there is thus an unmet medical need for non-invasive, sensitive, and quantitative methods for the assessment of fibrotic processes.
Olof Eriksson, Irina Velikyan
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