Results 61 to 70 of about 24,433 (235)

Why are we failing to implement imaging studies with radiolabelled new molecular entities in early oncology drug development? [PDF]

, 2014
In early drug development advanced imaging techniques can help with progressing new molecular entities (NME) to subsequent phases of drug development and thus reduce attrition.
Lahn, M, Murphy, P, Plisson, C, Saleem, A   +3 more
core   +3 more sources

Synthesis and Application of [18F]Togni Reagent I: An Electrophilic 18F‐Labeled Trifluoromethylating Reagent for Positron Emission Tomography Tracer Synthesis

European Journal of Organic Chemistry, EarlyView.
Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +1 more source

On the adsorption and reactivity of element 114, flerovium

Frontiers in Chemistry, 2022
Flerovium (Fl, element 114) is the heaviest element chemically studied so far. To date, its interaction with gold was investigated in two gas-solid chromatography experiments, which reported two different types of interaction, however, each based on the ...
A. Yakushev, A. Yakushev, L. Lens, L. Lens, Ch. E. Düllmann, Ch. E. Düllmann, Ch. E. Düllmann, J. Khuyagbaatar, J. Khuyagbaatar, E. Jäger, J. Krier, J. Runke, J. Runke, H. M. Albers, M. Asai, M. Block, M. Block, M. Block, J. Despotopulos, A. Di Nitto, A. Di Nitto, K. Eberhardt, U. Forsberg, P. Golubev, M. Götz, M. Götz, M. Götz, S. Götz, S. Götz, S. Götz, H. Haba, L. Harkness-Brennan, R.-D. Herzberg, F. P. Heßberger, F. P. Heßberger, D. Hinde, A. Hübner, D. Judson, B. Kindler, Y. Komori, J. Konki, J.V. Kratz, N. Kurz, M. Laatiaoui, M. Laatiaoui, M. Laatiaoui, S. Lahiri, B. Lommel, M. Maiti, A. K. Mistry, A. K. Mistry, Ch. Mokry, Ch. Mokry, K. J. Moody, Y. Nagame, J. P. Omtvedt, P. Papadakis, V. Pershina, D. Rudolph, L.G. Samiento, T.K. Sato, M. Schädel, P. Scharrer, P. Scharrer, P. Scharrer, B. Schausten, D. A. Shaughnessy, J. Steiner, P. Thörle-Pospiech, P. Thörle-Pospiech, A. Toyoshima, N. Trautmann, K. Tsukada, J. Uusitalo, K.-O. Voss, A. Ward, M. Wegrzecki, N. Wiehl, N. Wiehl, E. Williams, V. Yakusheva, V. Yakusheva   +81 more
doaj   +1 more source

Focal Spot, Spring/Summer 1980 [PDF]

, 1980
https://digitalcommons.wustl.edu/focal_spot_archives/1026/thumbnail ...

core   +1 more source

Rapid iododeboronation with and without gold catalysis: application to radiolabelling of arenes [PDF]

, 2017
Radiopharmaceuticals incorporating radioactive iodine in combination with SPECT imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis.
Fletcher, Conor, Lee, Ai-Lan, O'Rourke, Kerry M., Pimlott, Sally L., Sutherland, Andrew, Webster, Stacey   +5 more
core   +2 more sources

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Radiochemistry

Chemistry International, 2014
Citation: 'radiochemistry' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.R05099 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

One‐year follow‐up after fractionated ultra‐high‐dose‐rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum

Precision Radiation Oncology, EarlyView.
An elderly male patient with extramammary Paget disease of the scrotum and multiple metastases was treated with fractionated FLASH‐RT (40 Gy in 5 fractions) in the scrotal lesion. Abstract Objective Ultrahigh‐dose‐rate radiotherapy (FLASH‐RT) has been shown to reduce radiation‐induced normal tissue injury in preclinical studies.
Hui Luo, Chengliang Yang, Ronghu Mao, Leijie Ma, Hongchang Lei, Peng Chen, Yanping Zhang, Meng Xu, Chao Wang, Yiwu Wang, Mingxia Wu, Chanjun Sun, Han Liu, Hui Liu, Hong Ge   +14 more
wiley   +1 more source

Свет и тени «новой алхимии» [PDF]

, 2002
Явления радиоактивности, деления тяжелых ядер и ядерного синтеза легли в основу новых направлений в науке и технике - ядерной физики, радиохимии, атомной энергетики.
Егоров, Ю. В.
core  

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source