Results 71 to 80 of about 27,411 (234)

C–H Labeling with [18F]Fluoride: An Emerging Methodology in Radiochemistry

ACS Central Science
Fluorine-18 is the most routinely employed radioisotope for positron emission tomography, a dynamic nuclear imaging modality. The radiolabeling of C–H bonds is an attractive method for installing fluorine-18 into organic molecules since it can preclude ...
Jay S Wright, Liam S. Sharninghausen, Alex Lapsys, Melanie S. Sanford, Pete Scott   +4 more
semanticscholar   +1 more source

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +1 more source

Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, 44Sc‐Radiolabeling, and Preclinical Assessment

Chemistry – A European Journal, EarlyView.
Hypoxia‐sensitive nitroimidazole‐functionalized pyclen derivatives were successfully synthesized and radiolabeled with 44Sc(III), affording stable and inert scandium complexes. Remarkable Sc(III)‐binding capabilities of the PC2A‐mono(amide) platform enabled excellent radiolabeling performance, with ≥92–99% yields and ≥99% radiochemical purity. MicroPET
Tibor Csupász, Bayar Dahman, Tamás Gyula Gál, István Kapus, Zita Képes, Dániel Szücs, György Trencsényi, Imre Tóth, Anikó Fekete, Gyula Tircsó   +9 more
wiley   +1 more source

Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation [PDF]

, 2013
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated.
Carlin, Stephen M., Hooker, Jacob M, Kamlet, Adam, Lee, Eunsung, Moseley, Christian K., Neumann, Constanze Nicole, Ritter, Tobias, Stephenson, Nickeisha A   +7 more
core   +3 more sources

First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale

Molecular Imaging, 2023
[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration.
Kimberly L. Desmond, Anton Lindberg, Armando Garcia, Junchao Tong, Michael B. Harkness, Elena Dobrota, Kelly Smart, Carme Uribe, Jeffrey H. Meyer, Sylvain Houle, Antonio P. Strafella, Songye Li, Yiyun Huang, Neil Vasdev   +13 more
doaj   +1 more source

One‐pot Base‐free Suzuki‐Miyaura [11C]Methylation: Kinetic and Mechanistic Insights

Chemistry – A European Journal, EarlyView.
A base‐free Suzuki–Miyaura [11C]methylation is achieved in a one‐pot process with [11C]CH3I on moderate yields. Electronic effects enable transmetallation without boronate activation, while kinetics and DFT show oxidative addition (heterolytic) as the rate‐limiting step.
Oscar Moreno, Imad Azzeggarh, Jason P. Holland, Albert D. Windhorst, Jordi Llop   +4 more
wiley   +1 more source

One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents [PDF]

, 2017
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described.
Luthra, Sajinder K., McRobbie, Graeme, Pimlott, Sally L., Sloan, Nikki L., Sutherland, Andrew   +4 more
core   +2 more sources

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Pharmaceuticals, 2022
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann   +12 more
doaj   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]

, 2019
BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying, Clark, Peter M, Fong, Kelly Mun-Ming, Lisova, Ksenia, van Dam, R Michael, Wang, Jia   +5 more
core   +1 more source