Results 61 to 70 of about 13,411 (297)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial

Emerging Microbes and Infections, 2023
Epidemiological and interventional studies have been rarely conducted among those with positive interferon-γ release assay (IGRA) results and radiologically inactive tuberculosis (TB) lesions on chest radiograph.
Haoran Zhang, Henan Xin, Ying Du, Xuefang Cao, Shouguo Pan, Jianmin Liu, Ling Guan, Fei Shen, Zisen Liu, Bin Zhang, Dakuan Wang, Boxuan Feng, Jiang Du, Xueling Guan, Yijun He, Yongpeng He, Zhanjiang Zhang, Jiaoxia Yan, Qi Jin, Lei Gao   +19 more
doaj   +1 more source

The utility of three-dimensional dynamic contrast-enhanced

, 2010
Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors.
Nagatsuka, Hitoshi, Yanagi, Yoshinobu, Konouchi, Hironobu, Hisatomi, Miki, Mariko Fujita, Asaumi, Jun-ichi, Hironobu Konouchi, Hidenobu Matsuzaki, Katase, Naoki, Yoshinobu Yanagi, Hitoshi Nagatsuka, Matsuzaki, Hidenobu, Fujita, Mariko, Miki Hisatomi, Naoki Katase, Jun-ichi Asaumi   +15 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Percutaneous retrieval of symptomatic bone cement embolus from the pulmonary artery

Annals of Vascular Surgery - Brief Reports and Innovations
Bone cement pulmonary embolism (CPE) is not a rare complication. Most cases are asymptomatic and detected incidentally. In this study, we reported a female patient who was suffering from hemoptysis. To address this condition, our clinical group performed
Tiequan Yang, Dehai Lang, Zuanbiao Yu
doaj   +1 more source

Imaging in the Lion City: Singapore Radiology Country Report

Journal of Global Radiology, 2016
Singapore is a small tropical island city-state with limited natural resources that has achieved remarkable healthcare outcomes through effective long-term planning and judicious investment in human resources and technology.
Lionel Tim-Ee Cheng, Li Hoon Sng, Tchoyoson Choie Cheio Lim, Bien Soo Tan   +3 more
doaj   +1 more source

Preliminary study of endovascular intervention for cephalic arch stenosis under ultrasonic guidance with radiography

Linchuang shenzangbing zazhi, 2022
ObjectiveTo summarize the clinical experiences of endovascular treatment of cephalic arch stenosis under ultrasonic guidance with radiograph.MethodsFrom January 2017 to December 2020，clinical data were reviewed for patients of arteriovenous access malfunction and cephalic arch stenosis.Endovascular intervention was performed for cephalic arch stenosis ...
Zhang Li-hong, Zhan Shen, Xiao Guang-hui, Wang Yu-zhu   +3 more
openaire   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Enhancing evidence-based practice in radiography education: Evaluation of an applied curriculum intervention

Radiography
It is imperative that radiography graduates are taught to effectively apply evidence-based practice (EBP) in their clinical careers. Teaching the concept is challenging, as it requires educators to embed and scaffold knowledge and skills across the EBP cycle throughout both academic and clinical curricula. The objective of this study was to evaluate an
L. Di Michele, K. Thomson, A. Bell, W. Reed   +3 more
openaire   +2 more sources