Results 61 to 70 of about 13,275 (264)

R-AI-diographers: a European survey on perceived impact of AI on professional identity, careers, and radiographers’ roles

Insights into Imaging
Objectives Radiographers use advanced medical imaging and radiotherapy (MIRT) equipment. They are also a digitally mature and digitally resilient workforce in healthcare.
Nikolaos Stogiannos, Gemma Walsh, Benard Ohene-Botwe, Kevin McHugh, Ben Potts, Winnie Tam, Chris O’Sullivan, Anton Sheahan Quinsten, Christopher Gibson, Rodrigo Garcia Gorga, David Sipos, Elona Dybeli, Moreno Zanardo, Cláudia Sá dos Reis, Nejc Mekis, Carst Buissink, Andrew England, Charlotte Beardmore, Altino Cunha, Amanda Goodall, Janice St John-Matthews, Mark McEntee, Yiannis Kyratsis, Christina Malamateniou   +23 more
doaj   +1 more source

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu, Shuchang Zhou, Qin Peng, Xiao Bao, Xiaodan Ye, Ahmet Görkem Er, Tong Tong, Mirabela Rusu, Yajia Gu, Mailin Chen, Jing Gong   +10 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Advancements in Acute Pulmonary Embolism Diagnosis and Treatment: A Narrative Review of Emerging Imaging Techniques and Intravascular Interventions

Journal of Cardiovascular Development and Disease
Acute pulmonary embolism (APE) represents a significant cause of morbidity and mortality worldwide, requiring rapid and precise diagnosis and effective therapy strategies.
Michaela Cellina, Matilde Pavan, Niccolò Finardi, Francesco Cicchetti, Maurizio Cè, Pierpaolo Biondetti, Carolina Lanza, Serena Carriero, Gianpaolo Carrafiello   +8 more
doaj   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Causal relationship between metabolites and embolic stroke: based on Mendelian randomization and metabolomics

Frontiers in Neurology
PurposeThis research employed Mendelian randomization (MR) methods to explore whether metabolites are causally associated with embolic stroke of undetermined source (ESUS).MethodsGenome-Wide Association Study (GWAS) data regarding metabolites and ESUS ...
Ying Hang, Zanhao Chen, Jiayi Ren, Yu Wang, Kangle Zhu, Qianhong Zhu   +5 more
doaj   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

Successful Removal and Replacement of a Stuck Hemodialysis Catheter via Thoracotomy: Report of Two Cases and Literature Review

Case Reports in Nephrology and Dialysis
Introduction: Stuck tunneled central venous catheters (CVCs) have been increasingly reported. In rare cases, the impossibility of extracting the CVC from the central vein after regular traction is the result of rigid adhesions to the surrounding fibrin ...
Yanqin Fan, Dejiao He, Jing Cheng, Zhenzhong Wu, Yiqun Hao, Hongyan Liu   +5 more
doaj   +1 more source