Results 81 to 90 of about 13,411 (297)

A cross-sectional survey of the diagnosis and management of bone metastasis in breast cancer patients in Turkey [PDF]

, 2014
This study aimed to report the practice of managing breast cancer with bone metastasis in Turkey and to determine the adherence to the British Association of Surgical Oncology (BASO) guidelines.
Zumrut Bahat, Fatih Ozdener, Feyyaz Ozdemir, Pekin, Bahadir, Tulin Bozkurt, Idris Yucel, Gemici, Cengiz, Kazim Uygun, Abdurrahman Isikdogan, Bahadir Pekin, Camci, Celalettin, Mustafa Yildiz, Bozcuk, Hakan, Buyukberber, Suleyman, Uygun, Kazim, Binnaz Demirkan, Bese, Nuran Senel, Celalettin Camci, Bahat, Zumrut, Isikdogan, Abdurrahman, Demiray, Mutlu, Arican, Ali, Ozdemir, Feyyaz, Suleyman Buyukberber, Ali Arican, Bozkurt, Tulin, Hakan Bozcuk, Cengiz Gemici, Yucel, Idris, Sanli, Ulus Ali, Isik Aslay, Yildiz, Mustafa, Alkis, Necati, Mutlu Demiray, Demirkan, Binnaz, Nuran Senel Bese, Necati Alkis, Ulus Ali Sanli, Ozdener, Fatih, Aslay, Isik   +39 more
core   +2 more sources

Advancements in Acute Pulmonary Embolism Diagnosis and Treatment: A Narrative Review of Emerging Imaging Techniques and Intravascular Interventions

Journal of Cardiovascular Development and Disease
Acute pulmonary embolism (APE) represents a significant cause of morbidity and mortality worldwide, requiring rapid and precise diagnosis and effective therapy strategies.
Michaela Cellina, Matilde Pavan, Niccolò Finardi, Francesco Cicchetti, Maurizio Cè, Pierpaolo Biondetti, Carolina Lanza, Serena Carriero, Gianpaolo Carrafiello   +8 more
doaj   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Causal relationship between metabolites and embolic stroke: based on Mendelian randomization and metabolomics

Frontiers in Neurology
PurposeThis research employed Mendelian randomization (MR) methods to explore whether metabolites are causally associated with embolic stroke of undetermined source (ESUS).MethodsGenome-Wide Association Study (GWAS) data regarding metabolites and ESUS ...
Ying Hang, Zanhao Chen, Jiayi Ren, Yu Wang, Kangle Zhu, Qianhong Zhu   +5 more
doaj   +1 more source

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu, Shuchang Zhou, Qin Peng, Xiao Bao, Xiaodan Ye, Ahmet Görkem Er, Tong Tong, Mirabela Rusu, Yajia Gu, Mailin Chen, Jing Gong   +10 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Monte Carlo PENRADIO software for dose calculation in medical imaging [PDF]

, 2013
International audienceThe increase on the collective radiation dose due to the large number of medical imaging exams has led the medical physics community to deeply consider the amount of dose delivered to patients as well as its associated risks in ...
Lòpez Noriega, Mercedes, Mercedes Lòpez Noriega, Le Loirec, Cindy, Camille Adrien, Jean-Marc Bordy, Bénédicte Poumarede, Poumarède, Bénédicte, bordy, jean-marc, Cindy Le Loirec, Guillaume Bonniaud, Adrien, Camille, Bonniaud, Guillaume   +11 more
core   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Role of high magnification specimen radiography in surgical and core biopsies of the breast

, 2000
The clinical relevance of a high magnification specimen radiography (HMSR) system in breast biopsies was evaluated and compared with conventional specimen radiography with a mammography system (SRM).
Westerhof, J. P., Mertens, C., Oestmann, J. W., Moritz, J. D.   +3 more
core   +1 more source

Successful Removal and Replacement of a Stuck Hemodialysis Catheter via Thoracotomy: Report of Two Cases and Literature Review

Case Reports in Nephrology and Dialysis
Introduction: Stuck tunneled central venous catheters (CVCs) have been increasingly reported. In rare cases, the impossibility of extracting the CVC from the central vein after regular traction is the result of rigid adhesions to the surrounding fibrin ...
Yanqin Fan, Dejiao He, Jing Cheng, Zhenzhong Wu, Yiqun Hao, Hongyan Liu   +5 more
doaj   +1 more source