Results 151 to 160 of about 111,141 (252)

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

Current Status and Challenges of Imaging‐Based Diagnosis of Lymph Node Metastasis in Colon Cancer: The Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This review of the status and challenges of diagnosis of lymph node metastasis in colon cancer suggests that it is currently difficult to establish strict criteria for lymph node metastasis, indicating only moderate diagnostic performance. ABSTRACT Background Accurate pre‐treatment evaluation of lymph node metastasis (LNM) in colon cancer is important ...
Shimpei Ogawa   +4 more
wiley   +1 more source

Radiation protection of the patient in diagnostic radiology and nuclear medicine. Are we doing enough?

open access: yes, 2011
This paper deals with the radiation protection of patients in diagnostic radiology and nuclear medicine. Modern equipment like CT, PET/CT and SPECT/CT are very important in the daily hospital routine and there is a risk to overuse them, which results in ...
Mattsson, Sören
core  

When Biology Meets Medicine: A Perspective on Foundation Models

open access: yesAdvanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu   +3 more
wiley   +1 more source

Nuclear medicine physics: the basics

open access: yes, 2012
For decades this classic reference has been the book to review to master the complexities of nuclear-medicine physics. Part of the renowned The Basics series of medical physics books, Nuclear Medicine Physics has become an essential resource for ...
Chandra, Ramesh
core  

A Review on Current Challenges and Knowledge Gaps in Artificial Stone Silicosis

open access: yesAmerican Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The global emergence of artificial stone (AS) silicosis represents a critical occupational health challenge. The aim of this systematic review is to provide an overview of the clinical, functional, radiological, and occupational characteristics of patients affected by AS silicosis at the time of diagnosis, and to identify current ...
Paola Mason   +8 more
wiley   +1 more source

Nasal Tuft Cell Markers Are Predictive of Overall Survival in Sinonasal Neuroendocrine and Sinonasal Undifferentiated Carcinomas

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are rare aggressive malignancies with no established prognostic markers. Because features of POU2F3+ small cell lung carcinomas have been identified in both tumors, we evaluated immunostaining for POU2F3, a tuft cell transcription factor, and ...
Nikolina Dioufa   +6 more
wiley   +1 more source

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

open access: yesAnnals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola   +14 more
wiley   +1 more source

RADIOLOGY: A COMPREHENSIVE GUIDE FOR MEDICAL PROFESSIONALS [PDF]

open access: yes
Radiology is an indispensable tool in modern medicine, providing critical information for diagnosing, managing, and monitoring various diseases and conditions.
Fayziyev, Fazliddin Shabonovich
core  

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