Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT) [PDF]
Journal of Hematology & Oncology, 2022 The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT).
Michal Grzmil +8 more
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A Review on Tumor Control Probability (TCP) and Preclinical Dosimetry in Targeted Radionuclide Therapy (TRT) [PDF]
Pharmaceutics, 2022 Targeted radionuclide therapy (TRT) uses radiopharmaceuticals to specifically irradiate tumor cells while sparing healthy tissue. Response to this treatment highly depends on the absorbed dose.
Kaat Spoormans +4 more
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Pharmaceutics, 2021 In recent years, radionuclide therapy (RT) and targeted radionuclide therapy (TRT) have gained great interest in cancer treatment. This is due to promising results obtained in both preclinical and clinical studies.
Tyrillshall S. T. Damiana +1 more
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The evolving role of targeted radioligand therapy in small cell and non-small cell lung cancer: a systematic review [PDF]
Exploration of Targeted Anti-tumor TherapyBackground: Targeted radioligand therapy (TRT) is an emerging theranostic modality in oncology. While well established in neuroendocrine and prostate cancers, its role in small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) remains ...
Serin Moghrabi +8 more
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Introduction to radiobiology of targeted radionuclide therapy
Frontiers in Medicine, 2015 During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRT) are based on a multidisciplinary approach that involves the cooperation of specialists in ...
Jean-Pierre ePOUGET +6 more
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FAP-Targeted Radionuclide Therapy: Mechanisms, Clinical Applications, and Combination Strategies [PDF]
BiomedicinesThe fibroblast activation protein (FAP) has emerged as a compelling theranostic target because it is highly expressed in the tumour microenvironment of many solid malignancies, predominantly on cancer-associated fibroblasts and, in selected tumour types,
Ayça Arçay Öztürk +3 more
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Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer [PDF]
Cancer InnovationIn recent years, multidisciplinary treatment strategies have profoundly improved drug responses and survival outcomes of breast cancer (BC) patients. However, there is an urgent need for novel therapies for BC patients who are heavily treated or develop ...
Yujing Tan +3 more
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Integrated Radiobiotherapy: A State-Based Framework for Response-Adaptive Combination Oncology [PDF]
Current OncologyBackground: Cancer care increasingly requires coordinated use of systemic therapy, targeted radionuclide therapy (TRT), and external-beam radiotherapy (EBRT), yet clinical workflows often remain organized around static staging and sequential specialty ...
Srinivasan Vijayakumar +2 more
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Cellular responses to targeted radionuclide therapy: rethinking radiobiology under continuous low dose rates [PDF]
Frontiers in OncologyTargeted radionuclide therapy (TRT) delivers ionizing radiation directly to cancer cells through radio molecules that bind tumor-associated targets. Clinically successful examples include somatostatin receptor-directed TRT for neuroendocrine tumors, and ...
Pleun A.M. Engbers +2 more
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An overview of the role of radionuclides in targeted cancer treatment: application of biomarkers for patient selection and developments to improve treatment efficacy [PDF]
Frontiers in OncologyRadiopharmaceuticals for targeted radionuclide therapy (TRT) of tumours consist of a radionuclide conjugated to a component that can target the cancer. Several TRT radiopharmaceuticals have been licensed for the treatment of lymphoma, neuroendocrine and ...
Tim A. D. Smith, Tim A. D. Smith
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