Results 211 to 220 of about 111,141 (252)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Early Cessation of Adjuvant Anti‐PD‐1 Therapy in Stage III and IV Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT One year of adjuvant anti‐PD‐1 has improved disease‐free survival in Stage III melanoma. It is unknown whether shorter treatment duration affects outcomes. Real‐world data may help clarify this. In this retrospective observational study, patients with resected Stage III/IV melanoma receiving adjuvant anti‐PD‐1 in the Netherlands from 2018 to ...
Manja Bloem, Melissa M. de Meza, Cato D. M. Boreel, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Christian U. Blank, Willeke A. M. Blokx, Marye J. Boers‐Sonderen, Han J. Bonenkamp, Jan Willem B. de Groot, John B. Haanen, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Bart Rikhof, Lieke H. J. Simkens, Marion A. Stevense‐den Boer, Astrid A. M. van der Veldt, Karijn P. M. Suijkerbuijk, Alfonsus J. M. van den Eertwegh, Michel W. J. M. Wouters   +20 more
wiley   +1 more source

ChatGPT-4-Based Automated Preliminary Clinical Reporting in Myocardial Perfusion Imaging: A Pilot Evaluation. [PDF]

Diagnostics (Basel)
Keskin M, Oğuz E.
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Dose-Response and survival analysis after transarterial radioembolization for intrahepatic cholangiocarcinoma: A multicenter multicompartment dosimetry study. [PDF]

Eur J Nucl Med Mol Imaging
Soydal C, Ones T, Bozkurt MF, Isık EG, Selcuk NA, Coskun N, Kutlu R, Akkas BE, Onner H, Gultekin A, Ince S, Ozbay P, Karacavus S, Mesci I, Soydemir E, Salancı BV, Deniz G, Topcuoğlu OM, Ozdemir E, Otlu M, Kaya EM, Nayman A, Arslan M, Peker H, Ballı HT, Bilgili M, Celebioglu EC, Arik E, Eldem G, M D, Poyanli A, Toklu T, Ozdemir M, Kaya M, Dilek I, Celik A, Yuce G, Demir F, Kucuk NO.   +38 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Ectopic thyroid tissue in the breast mimicking a breast lesion: A rare case report. [PDF]

Radiol Case Rep
Holmesi H, Taghavi M, Rahmani S, Moyle P.   +3 more
europepmc   +1 more source

Flow Cytometry‐Guided Diagnosis of Cortical T‐Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background T‐cell lymphoblastic lymphoma (T‐LBL) and T‐cell acute lymphoblastic leukemia (T‐ALL) are considered a single biological entity, distinguished primarily by the extent of bone marrow infiltration. This distinction becomes diagnostically challenging in patients with borderline marrow blast counts and predominantly extramedullary ...
Chen Glait‐Santar, Yakir Moshe, Itzhaki‐Alfia Ayelet, Ben‐Zion Katz   +3 more
wiley   +1 more source

Consideration of Statin Therapy in the Interpretation of Artificial Intelligence-Derived Coronary Artery Calcium Density. [PDF]

Korean J Radiol
Liu X.
europepmc   +1 more source

Flow Cytometric Lymphocyte Subset Enumeration for Lymphopenia Grading and C‐Reactive Protein‐Defined Inflammation Discrimination

Journal of Clinical Laboratory Analysis, EarlyView.
This study refines conventional lymphopenia grading by establishing optimized T‐cell cutoffs via flow cytometric lymphocyte subset profiling. Additionally, by evaluating individual subset performance (CD4+, CD8+, B, and NK cells), the framework integrates these counts to construct predictive models for infection‐associated inflammation.
Shicheng Li, Tingting Fu, Yang Yang, Yuwei Pu, Wenying Yan, Junjun Zhang   +5 more
wiley   +1 more source