Results 191 to 200 of about 554,841 (316)

Interpretable chronic obstructive pulmonary disease identification using chest X-ray radiomics: a multicenter study. [PDF]

Insights Imaging
Zhou Q, Zhai W, Zhou T, Wang Y, Zhou X, Lin X, Li J, Wu H, Dai Q, Ma Y, Xu F, Zhang H, Ge Y, Fan L.   +13 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Air embolism as a complication following CT-guided lung biopsy: A case report and literature review. [PDF]

Radiol Case Rep
Van Luong H, Van Cong C, Tam TN, Cuong VM, Vu LT, Viet DQ, Hung ND, Long NT, Loc TQ.   +8 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Correction: Development of a machine learning model for predicting the expression of proteins associated with targeted therapy in endometrial cancer. [PDF]

Front Oncol
Sun C, Li Q, Huang Y, Xia Y, Li M, Zhu X, Zhu J, Zhao Z.   +7 more
europepmc   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Diagnostic accuracy of AI-assisted chest radiographs in tuberculosis screening: A Ghanaian clinical study. [PDF]

PLoS One
Sule DS, Kyei KA, Antwi WK, Acquah G, Dzefi-Tettey K, Daniels J, Nyantakyi AY.   +6 more
europepmc   +1 more source

Avulsion fracture of the tibial tubercle in an adolescent [PDF]

, 2016
Tack, Lieven, Van Crombrugge, Kris, Vanhoenacker, Charlotte, Vanhoenacker, Filip   +3 more
core   +2 more sources

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Correction: Sleep disorders in parkinson's disease: evaluating pharmacological treatments through systematic review and meta-analysis. [PDF]

BMC Neurol
Li J, Zhou R, Deng J, Zhou H, Hu J, Wang X.   +5 more
europepmc   +1 more source