Results 61 to 70 of about 173,192 (315)
Advanced Healthcare Materials, EarlyView.Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez +4 more
wiley +1 more source
PECULIARITY OF RADIONUCLIDES ACCUMULATION IN VARIOUS ORGANS OF VEGETABLE CROPS
Овощи России, 2015 The peculiarities of accumulation of radionuclides 137Cs and 90Sr in different organs and tissues of vegetable crops have been studied. Aim of this research was the enhancement of safety and quality of food at the cost of the elimination from the food ...
A. V. Soldatenko +2 more
doaj +1 more source
Advanced Science, EarlyView.Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu +12 more
wiley +1 more source
Comparison of technetium-99m IgG with technetium-99m red blood cells labeling in cardiac blood-pool scintigraphy: A preliminary study [PDF]
, 2011 This first clinical prospective study was conducted to use of technetium-99m immunoglobulin G (99mTc-IgG) as compared with autologous 99mTc-red blood cells (RBC) in gated blood pool ventriculography.
Amini, A. +7 more
core
Measurement of 139La(p,x) cross sections from 35–60 MeV by stacked-target activation [PDF]
, 2019 A stacked-target of natural lanthanum foils (99.9119% 139La) was irradiated using a 60 MeV proton beam at the LBNL 88-Inch Cyclotron. 139La(p,x) cross sections are reported between 35–60 MeV for nine product radionuclides. The primary motivation for this
Basunia, MS +5 more
core +3 more sources
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Imaging using radiolabelled targeted proteins: radioimmunodetection and beyond
EJNMMI Radiopharmacy and Chemistry, 2020 The use of radiolabelled antibodies was proposed in 1970s for staging of malignant tumours. Intensive research established chemistry for radiolabelling of proteins and understanding of factors determining biodistribution and targeting properties. The use
Javad Garousi +3 more
doaj +1 more source
, 1999 Radionuclides with half-lives ranging from some years to billions of years presumably synthesized outside of the solar system are now recorded in ``live'' or ``fossil'' form in various types of materials, like meteorites or the galactic cosmic rays. They
Arnould, Marcel, Prantzos, Nikos
core +3 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine [PDF]
, 2011 There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I. C. Baianu
core +1 more source