Results 61 to 70 of about 186,306 (297)

Geant4 simulation study of β-γ coincidence detector for 41Ar measurement

He jishu
Background41Ar is one of the main radionuclides released into the environment by the operation of reactors and accelerators. The measurement of 41Ar activity concentration is of great significance for ensuring public health.
FENG Yajie, ZHANG Ruiqin, NIU Yazhou, LI Qi, TONG Lili, WANG Shilian, ZHAO Yungang, FAN Yuanqing, ZHANG Xinjun   +8 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Radiotheranostic Agents in Hematological Malignancies

Frontiers in Immunology, 2022
Radioimmunotherapy (RIT) is a cancer treatment that combines radiation therapy with tumor-directed monoclonal antibodies (Abs). Although RIT had been introduced for the treatment of CD20 positive non-Hodgkin lymphoma decades ago, it never found a broad ...
Jo Caers, Jo Caers, Elodie Duray, Elodie Duray, Louise Vrancken, Louise Vrancken, Guillaume Marcion, Valentina Bocuzzi, Kim De Veirman, Ahmet Krasniqi, Margaux Lejeune, Nadia Withofs, Nick Devoogdt, Mireille Dumoulin, Amelie Eriksson Karlström, Matthias D’Huyvetter   +15 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

64Cu-SARTATE PET Imaging of Patients with Neuroendocrine Tumors Demonstrates High Tumor Uptake and Retention, Potentially Allowing Prospective Dosimetry for Peptide Receptor Radionuclide Therapy

Journal of Nuclear Medicine, 2018
Imaging of somatostatin receptor expression is an established technique for staging of neuroendocrine neoplasia and determining the suitability of patients for peptide receptor radionuclide therapy.
R. Hicks, P. Jackson, G. Kong, R. Ware, M. Hofman, D. Pattison, T. Akhurst, E. Drummond, P. Roselt, J. Callahan, R. Price, Charmaine M. Jeffery, E. Hong, Wayne Noonan, A. Herschtal, Lauren J. Hicks, Amos Hedt, Matthew J. Harris, Brett M. Paterson, P. Donnelly   +19 more
semanticscholar   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Targeted Alpha Particle Therapy for Neuroendocrine Tumours: The Next Generation of Peptide Receptor Radionuclide Therapy

Neuroendocrinology, 2018
Neuroendocrine tumours (NETs) are being seen increasingly frequently, but to date only complete surgical resection is curative. However, among the various therapeutic options, peptide receptor radionuclide therapy, linking a radioactive moiety to an ...
S. Navalkissoor, A. Grossman
semanticscholar   +1 more source

Metal Complexes Containing Natural and and Artificial Radioactive Elements and Their Applications

Molecules, 2014
Recent advances (during the 2007–2014 period) in the coordination and organometallic chemistry of compounds containing natural and artificially prepared radionuclides (actinides and technetium), are reviewed.
Oxana V. Kharissova, Miguel A. Méndez-Rojas, Boris I. Kharisov, Ubaldo Ortiz Méndez, Perla Elizondo Martínez   +4 more
doaj   +1 more source

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

Analysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann, Tim Schmalz, Tobias Weissenborn, Felix Stäger, Beate Riebe, Clemens Walther   +5 more
wiley   +1 more source

Under the Shade of a Coolabah Tree: A Second Cache of Tulas From the Boulia District, Western Queensland

Archaeology in Oceania, EarlyView.
ABSTRACT This paper reports on the excavation of a cache of stone artefacts, buried on the bank of a waterhole or ‘billabong’ in central western Queensland. This is an extremely rare find, and yet it is the second such site to be reported within less than a 10 km radius.
Yinika L. Perston, Lynley A. Wallis, Heather Burke, Lorna Bogdanek, Trevina Rogers, Justine Kemp   +5 more
wiley   +1 more source