Results 51 to 60 of about 38,524 (259)
Chelator‐Free Radiometal Labeling Inside Engineered Affibodies
Angewandte Chemie, EarlyView.Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies +6 more
wiley +2 more sources
World Journal of Nuclear Medicine, 2020 In recent years, lutetium-177 (177Lu)-labeled prostate-specific membrane antigen (PSMA)-617 has become a promising new therapeutic agent in patients with metastatic castration-resistant prostate cancer (mCRPC).
Majid Assadi +9 more
doaj +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule
Scientific Reports, 2017 Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy.
Javad Garousi +10 more
doaj +1 more source
Cardiac radionuclide imaging after coronary artery revascularization
, 2014 In the last decades, advances in the therapeutic options for cardiovascular diseases, coupled with improvements in imaging technology contributed to the explosive growth in the number of cardiovascular imaging procedures performed, which also raised ...
PETRETTA, MARIO +4 more
core +1 more source
Advanced Science, EarlyView.Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza +9 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Appropriate Use of Radionuclide Imaging
, 2012 The growth of radionuclide imaging has raised well-founded concerns about potential overutilization. In response to the need for guidance, appropriate use criteria have been developed, which categorize specific clinical scenarios such as whether ...
Sager, Solomon J +3 more
core +1 more source
Advanced Science, EarlyView.This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma +10 more
wiley +1 more source
Advanced Science, EarlyView.Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen +6 more
wiley +1 more source