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Clinical Radionuclide Therapy [PDF]
, 2008 Clinical applications of targeted radionuclide treatment have evolved considerably over the last 10–20 years, principally as a result of an improved understanding of tumour biology, and the identification of biochemical pathways and protein targets expressed preferentially on tumours compared to normal tissue.
Andrew M. Scott +3 more
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Radionuclides and carrier molecules for therapy [PDF]
Physics in Medicine and Biology, 1996 Although radionuclide therapy has been around for a long time, this modality of cancer treatment has been limited mainly to the use of [32P]-phosphate and [131I]-sodium iodide. The last few years, however, have seen an increased interest in this area due to new developments of radionuclides and carrier molecules that may provide selective targeting of ...
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Radionuclide Therapy in Melanoma
2012Melanoma is being diagnosed more often than ever before. This may be due in part to greater vigilance but there is, nevertheless, a steadily increasing incidence of the disease in the western world. Melanoma accounts for less than 5 % of skin cancers but is the cause of more than 80 % of deaths from skin cancer, and the loss of life years is amplified ...
Robert Howman-Giles +2 more
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Radionuclide Therapy of Leukemias [PDF]
, 2012 Leukemia is currently the most common fatal cancer in the United States among males younger than 40 years old, whereas bronchopulmonary cancer predominates in men aged 40 years and older. Among females, leukemia is the leading cause of cancer death before age 20 years, breast cancer ranks first at ages 20–59 years, and lung cancer ranks first at ages ...
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The use of radionuclides for tumor therapy
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1986The successful use of radionuclides for tumor therapy depends to a major extent on the ability to achieve a high concentration of radioactivity in the tumor relative to other radiosensitive organs not involved by tumor, such as bone marrow, intestinal mucosa, liver, and kidneys.
Rashid A. Fawwaz +3 more
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Radionuclide therapy of adrenal tumors
Journal of Surgical Oncology, 2012AbstractAdrenal tumors arising from chromaffin cells will often accumulate radiolabeled metaiodobenzylguanidine (MIBG) and thus are amenable to therapy with I‐131 MIBG. More recently, therapy studies have targeted the somatostatin receptors using Lu‐177 or Y‐90 radiolabeled somatostatin analogs.
Jorge A. Carrasquillo +2 more
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Radionuclide therapy beyond radioiodine
Wiener Medizinische Wochenschrift, 2012For decades, Iodine-131 has been used for the treatment of patients with thyroid cancer. In recent years, increasingly, other radiopharmaceuticals are in clinical use in the treatment of various malignant diseases. Although in principle these therapies-as in all applications of radionuclides-special radiation protection measures are required, a ...
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Beta-Emitting Radionuclides for Peptide Receptor Radionuclide Therapy
Current Topics in Medicinal Chemistry, 2013The paper focuses on the β-emitting radionuclides which might be useful for peptide receptor radionuclide therapy, PRRT. For the effective design of the radiopharmaceutical, the choice of radionuclide will depend on the purpose for which the radioligand is being used and on the physicochemical properties of the radionuclide.
Parus Jl, Mikolajczak R
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Introduction to Radionuclide Therapy
2008This introductory chapter is written for those who are new to the field and desire a short overview of the present status of clinical and preclinical radionuclide therapy. In particular, this chapter provides an overview of the radiophysical concepts and key aspects of dosimetry and treatment planning that are beyond the scope of this book’s focus on ...
Jörgen Carlsson +2 more
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2016
Therapeutic applications of alpha (α)-emitting radionuclides were introduced soon after the isolation of radium from pitch blende by Marie Curie in the early twentieth century. Because of the very high linear energy transfer (LET), α-emitters can be very lethal and result in very effective cell killing sterilization if the α-decay commences at the ...
Ashutosh Dash, Furn F. Knapp
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Therapeutic applications of alpha (α)-emitting radionuclides were introduced soon after the isolation of radium from pitch blende by Marie Curie in the early twentieth century. Because of the very high linear energy transfer (LET), α-emitters can be very lethal and result in very effective cell killing sterilization if the α-decay commences at the ...
Ashutosh Dash, Furn F. Knapp
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