Results 41 to 50 of about 34,670 (250)

Current Status and Research Trend on Ecological Migration of Radionuclides and Radiation Dose Assessment

Yuanzineng kexue jishu
The transport and transfer of radionuclides in the ecological environment (referred to migration) have long been of a particular concern in the field of radiological environmental protection.
LIU Senlin, WU Renjie, ZHANG Xinyu, LI Jinfeng
doaj   +1 more source

Element and radionuclide concentrations in soils and wildlife from forests in north-eastern England with a focus on species representative of the ICRP's Reference Animals and Plants [PDF]

Earth System Science Data, 2020
There are international recommendations that the environment (i.e. wildlife) is assessed for the potential impact of releases of ionizing radiation. The transfer of radionuclides to wildlife from media (e.g.
C. L. Barnett, N. A. Beresford, N. A. Beresford, M. D. Wood, M. Izquierdo, M. Izquierdo, L. A. Walker, R. Fawkes   +7 more
doaj   +1 more source

Long-term atmospheric fluxes of radionuclides at a coastal Mediterranean station [PDF]

, 2013
7Be is one of the radionuclide produced by spallation reactions of cosmic rays with light atmospheric nuclei. 7Be rapidly associates primarily with submicron-sized aerosol particles.
Cañete, Sergio, Dueñas-Buey, Mª Concepción, Fernández, M.C, Gordo, Elisa, Liger-Pérez, Esperanza, Perez-Martinez, Manuel   +5 more
core   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Modeling and field trials optimize crop-based phytoremediation of soils contaminated with radioactive strontium and cesium

Soil & Environmental Health
When agricultural soils are contaminated by strontium-90 (90Sr) and cesium-137 (137Cs), remediation is needed to ensure effective decontamination and food safety.
Tian Zhang, Shaofei Cao, Meie Wang, Siqi Liu, Yang Yang, Weiping Chen   +5 more
doaj   +1 more source

Specific arbuscular mycorrhizal fungal–plant interactions determine radionuclide and metal transfer into Plantago lanceolata

Plants, People, Planet, 2021
Societal Impact Statement Industrial activity has left a legacy of pollution by radionuclides and heavy metals. The exposure of terrestrial environments to increased levels of ionising radiation and toxic elements is of concern, not only because of the ...
Jeanette Rosas‐Moreno, Jon K. Pittman, Clare H. Robinson   +2 more
doaj   +1 more source

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

Molecular Therapy: Methods & Clinical Development, 2021
Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs has been shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical ...
Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L. Tung, Rosalind F. Hannen, Yasmin R. Mohseni, Cristiano Scotta, Federica M. Marelli-Berg, Robert I. Lechler, Lesley A. Smyth, Gilbert O. Fruhwirth, Giovanna Lombardi   +12 more
doaj   +1 more source

Advances in targeted Alpha therapy for prostate cancer [PDF]

, 2019
BACKGROUND: Amongst therapeutic radiopharmaceuticals, targeted alpha therapy (TαT) can deliver potent and local radiation selectively to cancer cells as well as the tumor microenvironment and thereby control cancer while minimizing toxicity.
De Vincentis, G, Gerritsen, W, Gschwend, JE, Hacker, M, Lewington, V, O'Sullivan, JM, Oya, M, Pacilio, M, Parker, C, Sartor, O, Shore, N, Targeted Alpha Therapy Prostate Working Group   +11 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source