Results 31 to 40 of about 110,471 (285)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Closed Fuel Cycle and Minor Actinide Multirecycling in a Gas-Cooled Fast Reactor

Science and Technology of Nuclear Installations, 2009
The Generation IV International Forum has identified the Gas-Cooled Fast Reactor (GCFR) as one of the reactor concepts for future deployment. The GCFR targets sustainability, which is achieved by the use of a closed nuclear fuel cycle where only fission ...
W. F. G. van Rooijen, J. L. Kloosterman
doaj   +1 more source

Dynamics of 137Cs content in the bark of Frangula alnus Mill. in the forests of Ukrainian Polissia

Ядерна фізика та енергетика, 2018
Results of long-term studies of 137Cs accumulation in the Frangula alnus Mill. bark in wet subory in forests of Ukrainian Polissia are presented. The reduction of specific activity of the radionuclide in the bark of this plant and the dependence of the ...
V. P. Krasnov, T. V. Kurbet, I. V. Davydova, Z. M. Shelest, O. V. Zhukovsky, I. D. Ivanyuk   +5 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Three-dimensional Numerical Modeling of Critical Pathways for Radionuclide East of Fukushima Entering China Seas

Yuanzineng kexue jishu
On August 24, 2023, the Japanese government officially discharged nuclear wastewater into the ocean, causing widespread international concern. Radionuclides in nuclear wastewater pose a serious threat to the marine environment and to the national health ...
LI Yuxuan1, , ZHAO Chang2, YANG Dezhou1, , XU Lingjing1
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Temporal analysis of natural radionuclides deposition at Málaga(2005-2016) [PDF]

, 2018
Atmospheric deposition of radionuclides has been investigated in many studies from the aspects of both radiation protection and geochemistry. The present study, carried out in the city of Málaga, in the southeast of Spain, focuses on the assessment of ...
Cabello, M C, Cañete, S, Dueñas-Buey, Mª Concepción, Gordo, Elisa, Liger-Pérez, Esperanza, Perez-Martinez, Manuel, Ruiz-Cruces, Rafael   +6 more
core  

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Extreme value theory applied to the millennial sunspot number series [PDF]

, 2018
In this work, we use two decadal sunspot number series reconstructed from cosmogenic radionuclide data (14C in tree trunks, SN-14C and 10Be in polar ice, SN-10Be) and the Extreme Value Theory to study variability of solar activity during the last 9 ...
Acero, F. J., Gallego, M. C., García, J. A., Usoskin, I. G., Vaquero, J. M.   +4 more
core   +2 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source