Results 81 to 90 of about 21,291 (235)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Environmental Contaminant Accumulation in Freshwater Turtles Inhabiting Three Rivers of the Permian Basin, New Mexico, USA

Environmental Toxicology, EarlyView.
ABSTRACT Freshwater turtles are valuable sentinels of aquatic systems due to their long lifespans and resilience in environments impacted by contaminants. The Permian Basin, dominated by the oil and gas sector, spans western Texas and southeastern New Mexico, USA, including the Pecos River and its tributaries, the Delaware and Black Rivers.
Ana G. G. Sapp, W. Gregory Cope, Christopher E. Moorman, Frank X. Weber, Ivana Mali   +4 more
wiley   +1 more source

PEACEFUL UNDERGROUND NUCLEAR EXPLOSIONS: CURRENT ISSUES ON RADIATION SAFETY FOR GENERAL PUBLIC

Радиационная гигиена, 2016
The paper contains brief summary of original and published radiological data relevant to the sites of peaceful underground nuclear explosions: «Globus-1»,«Dnepr-1,2», «Crystal», «Kraton-3», «Kraton-1», «Kimberlit-1», «Angara», «Quartz-3», «Benzol».The ...
V. P. Ramzaev, V. S. Repin, E. V. Khramtsov   +2 more
doaj  

Assessment Activity Concentrations of Rice Components (Root, Stem, Leaf, and Grain) and Transfer Factors (TF) from Paddy Soil to Rice Grain of Radionuclides ⁴⁰K, ²²⁶Ra, ²³²Th, and ¹³⁷Cs Investigation in Taiwan

Agronomy
This study analyzed the activity concentrations of various radionuclides in irrigation water, rice components, and corresponding soil samples from eleven paddy fields, revealing significant findings with potential environmental and health implications ...
Wei-Hsiang Huang, Ting-Chien Chen, Sheng-Chi Lin, Zhi-Mou Chen, Yi-Lung Yeh   +4 more
doaj   +1 more source

Cutting‐edge advances in bicyclic peptide‐based radiotracers for cancer imaging and theranostics

VIEW, EarlyView.
Abstract Along with successful clinical approval of radiopharmaceuticals targeting somatostatin receptor subtype 2 and prostate‐specific membrane antigen, peptide‐based radiotracers have garnered the increasing attention in cancer imaging and theranostics. As a newly emerging targeting ligand in recent years, bicyclic peptides have demonstrated immense
Hengyi Ou, Xiaobo Wang, Fei Kang
wiley   +1 more source

SOME DATA FOR SUBSTANTIATION OF CONTROLLING MICROELEMENT COMPOSITION OF HERBAL PLANT RAW MATERIALS

Разработка и регистрация лекарственных средств, 2019
The contents of natural radionuclides in camomile and of germanium element in some herbs and ginseng of different origin were determined by mass spectrometry and inductively coupled plasma atomic emission spectrometry.
B. A. Komarov, L. V. Pogorel´skaya, A. I. Albulov   +2 more
doaj  

A Multi‐Analytical Approach for the Compositional Characterization and Chronological Discrimination of Benin (Nigeria) Metal Sculptures

Archaeometry, EarlyView.
ABSTRACT This study presents a multi‐analytical archaeometric approach for the compositional characterization and chronological discrimination of Benin metal sculptures in relation to the 1897 Punitive Expedition. The methodology integrates elemental composition (XRF and ICP), stable lead isotope ratios (MC‐ICP‐MS) for alloy system characterization ...
I. Torraba, D. A. Ahumada, H. Bagán, A. Tarancón, S. Eisenhofer, J. F. García   +5 more
wiley   +1 more source

Coastal evolution, environmental change and carbon storage in the Thung Prong Thong Mangrove, eastern Gulf of Thailand

Boreas, EarlyView.
Palaeoenvironmental records along the eastern coast of Thailand remain sparse, with only a few studies attempting to reconstruct past climatic and environmental conditions. However, additional palaeoenvironmental, palaeoclimatic and sea‐level records are needed to improve our understanding of coastal evolution and local environmental changes.
Sakonvan Chawchai, Smith Leknettip, Naomi Seaton, Kannika Wangritthikraikul, Nathalie Dubois, Ludvig Löwemark, Pei‐Ling Wang, Frank Preusser   +7 more
wiley   +1 more source

Refining the timing of Middle Pleistocene (MIS 12 to MIS 6) ice advances into northern central Europe: sedimentological analysis and single‐grain luminescence dating of glaciotectonic complexes and tunnel‐valley fills

Boreas, EarlyView.
We summarize the current state of knowledge on the age of the Middle Pleistocene ice advances into northern central Europe and provide 25 new single‐grain feldspar luminescence ages of Elsterian and Saalian glacigenic sediments to constrain the age of the ice advances and their tentative correlation with marine isotope stages/substages.
Niklas von Soest, Neda Rahimzadeh, Debra Colarossi, Falko Malis, Tobias Lauer, Wera Sander‐Beuermann, Yvonne Spychala, Christian Brandes, Runa Fälber, Sumiko Tsukamoto, Jutta Winsemann   +10 more
wiley   +1 more source

In Vivo Imaging of the Innate Immune System in the Pancreas in New‐Onset and Long‐Standing Type 1 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Type 1 diabetes (T1D) is an autoimmune disease, but knowledge of immune cell infiltration in the human pancreas is limited due to the risks associated with pancreatic biopsies. This study aimed to evaluate the feasibility of imaging innate immune cells in vivo using positron emission tomography (PET).
Ebrahim Anvari, Hongchao Zhang, Henrik Hill, Nathalia Guarienti Missima, Per Liss, Irina Velikyan, Gunnar Antoni, Olle Korsgren, Daniel Espes, Olof Eriksson   +9 more
wiley   +1 more source