Results 121 to 130 of about 9,097 (242)
[[abstract]]Aim: Radiotherapy employs high-energy ionizing radiation to inflict DNA damage on cancer cells, thereby causing their demise. However, this procedure can inadvertently harm healthy tissue.
Chen, MH;Zeng, XH;Shu, YT;Liang, HK;Chen, CY;Lin, CY;Lin, CAJ;Chen, JK
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MedComm, Volume 7, Issue 11, November 2026.Radiation‐associated transcriptional and regulatory cell states drive heterogeneous radioresponses in isogenic lung adenocarcinoma cells. ABSTRACT Radioresistance severely compromises radiotherapy efficacy for lung adenocarcinoma (LUAD), yet the intrinsic heterogeneity of cellular radioresponses among isogenic tumor cells remains poorly characterized ...
Huan Tao +15 more
wiley +1 more source
Protein Lactylation in Cancer: From Mechanisms to Therapy
MedComm, Volume 7, Issue 11, November 2026.Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang +8 more
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Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer
Cancer Science, Volume 117, Issue 11, Page 2953-2966, November 2026.The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang +7 more
wiley +1 more source
Influence of Rosuvastatin and Meloxicam on Radiation-Induced Genetic Damage in Healthy Lymphocytes and Leukemia HL-60 Cells [PDF]
مجله دانشگاه علوم پزشکی گیلانBackground: Radiotherapy plays a crucial role in cancer treatment; however, a significant challenge is the resistance of cancer cells to radiation, as well as the adverse effects that ionizing radiation can have on adjacent healthy cells. Objective: This
Mona Haddad Zahmatkesh +3 more
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, 2017 We have identified AMRI-59, one of small molecule, is specific pharmaceutical inhibitor of peroxiredoxin (PRX) I enzyme activity in our previous study.
Ju Yeon Kim +7 more
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International Journal of Nanomedicine, 2020 Mengmeng Shang,1 Xiao Sun,1 Lu Guo,1 Dandan Shi,1 Ping Liang,2 Dong Meng,1 Xiaoying Zhou,1 Xinxin Liu,1 Yading Zhao,1 Jie Li1 1Department of Ultrasound, Qilu Hospital of Shandong University, Jinan 250012, People’s Republic of China; 2Department of ...
Shang M +9 more
doaj
Golden era of radiosensitizers
Frontiers in Veterinary ScienceThe past 30 years have brought undeniable progress in medicine, biology, physics, and research. Knowledge of the nature of the human body, diseases, and disorders has been constantly improving, and the same is true regarding their treatment and diagnosis. One of the greatest advances in recent years has been the introduction of nanoparticles (NPs) into
Čížková, Jana +6 more
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, 1999 文内综述了化学增敏剂的实验研究进展，由于放射增敏剂能提高肿瘤的治愈率，因此得到国内外有关学者的广泛研究This paper reviews the progresses in the radiosensitizer research.As a result of raising the cure of tumour,radiosensitizer has been widly ...
张力 +7 more
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Effectiveness of Gefitinib as additional Radiosensitizer to Conventional Chemoradiation for Locally advanced non-metastatic Squamous Cell Carcinoma of Head and Neck. Prospective interventional Randomized Controlled Study [PDF]
, 2012 Approximately 90% of head and neck squamous cell carcinoma (HNSCC) overexpress epidermal growth factor receptor (EGFR). EGFR plays a role in predicting and modulating the response of HNSCC patients to radiation.
Sharma, Shyam +3 more
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