Results 101 to 110 of about 27,469 (292)

Focal Spot, Fall/Winter 1988 [PDF]

, 1988
https://digitalcommons.wustl.edu/focal_spot_archives/1050/thumbnail ...

core   +1 more source

A three-in-one-bullet for oesophageal cancer: Replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator [PDF]

, 2017
Substitutionally inert ruthenium(II) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding modality are largely unexplored.
Baumann, Campisi, Carter, Chen, Cuello-Garibo, Deng, Fichter, Findlay, Friedman, Gill, Gill, Gill, Gill, Gill, Griffith, Hall, Hall, Hall, Hall, Holland, Howerton, Huang, Kleinberg, Koh, Lawrence, Liu, Liu, Mari, Mari, Maskey, Merrick, Mikhailov, Minshull, Müller, Niyazi, Notaro, O'Connor, Pierroz, Pierroz, Puckett, Ramirez, Ramu, Rogakou, Roos, Sears, Sehdev, Seiwert, Shapiro, Siddik, Smyth, Song, Szikriszt, Takahara, Tian, Turner, Tysoe, Vaz, Vogel, Wang, Wardman, Yadav, Zecevic, Zeglis, Zellweger, Zeng   +64 more
core   +2 more sources

Electron-Induced Dissociation of the Potential Radiosensitizer 5-Selenocyanato-2'-deoxyuridine.

Journal of Physical Chemistry B, 2019
5-Selenocyanato-2'-deoxyuridine (SeCNdU) is a recently proposed radiosensitizer based on 2'-deoxyuridine (dU) with the electron-affinic selenocyanato (-SeCN) side group attached at the C5 position of uracil. Since electron interaction processes may be an
R. Meißner, Samanta Makurat, Witold Kozak, P. Limão-Vieira, J. Rak, S. Denifl   +5 more
semanticscholar   +1 more source

Radiosensitizer–DNA interactions

The British Journal of Radiology, 1988
We have previously shown (Dennis et al, 1985; Watts & Jones, 1985) that measurements of uptake of the radiosensitizers misonidazole and the weak base pimonidazole (Ro 03–8799) show a good apparent correlation between average intra-cellular concentration and radiosensitization, when differences electron affinity are taken into account.
M R, Stratford, M F, Dennis, M E, Watts, R R, Watfa   +3 more
openaire   +2 more sources

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer

Cells, 2019
Background: Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to standard chemo- and radiotherapy. Recently, a new class of non-platinum-based halogenated molecules (called FMD compounds) was discovered that selectively kills cancer cells. Here,
Robert G. Goetze, Soeren M. Buchholz, Ning Ou, Qinrong Zhang, Shilpa Patil, Markus Schirmer, Shiv K. Singh, Volker Ellenrieder, Elisabeth Hessmann, Qing-Bin Lu, Albrecht Neesse   +10 more
doaj   +1 more source

Radiosensitization by BRAF inhibitor therapy—mechanism and frequency of toxicity in melanoma patients [PDF]

, 2015
This study shows radiosensitization by BRAF inhibitors in clinical practice and ex vivo by fluorescence in situ hybridization of chromosomal breaks.
Bauch, J., Berking, C., Clemens, P., Distel, L. V., Eich, H. T., Fietkau, R., Forschner, A., Gleisner, S., Goldinger, S. M., Grabbe, S., Grabenbauer, G., Gutzmer, R., Hecht, M., Heinzerling, L., Keikavoussi, P., Loquai, C., Müller-Brenne, T., Schadendorf, D., Schuler, G., Schulze, B., Schuster, B., Semrau, S., Weishaupt, C., Zimmer, L.   +23 more
core   +2 more sources

Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons

International Journal of Molecular Sciences, 2019
Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage.
R. Meißner, L. Feketeová, E. Illenberger, S. Denifl   +3 more
semanticscholar   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

AS1411 aptamer conjugated gold nanoclusters as a targeted radiosensitizer for megavoltage radiation therapy of 4T1 breast cancer cells

, 2018
In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. GNCs with an ultra-small gold core and a bovine serum albumin shell (BSA) as
Fatemeh Ghahremani, D. Shahbazi-Gahrouei, Amirhosein Kefayat, Hasan Motaghi, M. Mehrgardi, Shaghayegh Haghjooy Javanmard   +5 more
semanticscholar   +1 more source