Results 101 to 110 of about 9,097 (242)

Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer

, 2023
xCT overexpression in cancer cells has been linked to tumor growth, metastasis and treatment resistance. Sulfasalazine (SSZ), an FDA-approved drug for the treatment of rheumatoid sarthritis, and inflammatory bowel diseases, has anticancer properties via ...
Adrián Gutiérrez, Gutiérrez, Adrián, Corbet, Cyril, Cyril Corbet, Inès Dufait, Inge Oudaert, Oudaert, Inge, De Ridder, Mark, Gevaert, Thierry, Febe Geirnaert, Ka Lun Law, Dufait, Inès, Thierry Gevaert, Rifi, Amir Laraki, Kerkhove, Lisa, Law, Ka Lun, Lisa Kerkhove, Mark De Ridder, Geirnaert, Febe, Amir Laraki Rifi   +19 more
core   +1 more source

Autotaxin inhibition with PF8380 enhances the radiosensitivity of human and murine glioblastoma cell lines

Frontiers in Oncology, 2013
Purpose: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo and radiotherapy.
Sandeep R Bhave, Sandeep R Bhave, David YA dadey, David YA dadey, Rowan M Karvas, Daniel J Ferraro, Rama P Kotipatruni, Jerry J Jaboin, Andrew N Hallahan, Todd A DeWees, Amanda G Linkous, Dennis E Hallahan, Dennis E Hallahan, Dennis E Hallahan, Dennis E Hallahan, Dinesh eThotala, Dinesh eThotala   +16 more
doaj   +1 more source

Laser‐Synthesized Carbon‐Coated Elemental Bismuth Nanoparticles for Sustained Reactive Oxygen Species Generation Under Visible‐Light Irradiation

Small, EarlyView.
Femtosecond laser ablation of bismuth in acetone yields carbon‐coated nanoparticles with a metallic Bi0 core and an amorphous carbon shell. The core‐shell architecture preserves visible‐light‐driven redox activity and enables sustained hydroxyl‐radical generation.
Pavel Bezrukov, Sravan Sangeeth Surendran, Andrey Machnev, Andrei Pastukhov, Alexander Gumennik, Andrei Kabashin, Pavel Ginzburg   +6 more
wiley   +1 more source

Acute toxicity of cyclooxygenase-2 inhibitor rofecoxib as a radiosensitizer for concurrent chemoradiation in the treatment of uterine cervical cance [PDF]

, 2009
OBJECTIVE: To evaluate the acute toxicity of rofecoxib during concurrent use with cisplatin-based chemoradiotherapy (CCRT) in patients with cervical cancer.
김재욱, 이산희, 김상운, 남은지, 백지흠, 정용욱, 김재훈, 김영태   +7 more
core   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Clinical Testing of the Radiosensitizer Ro-07-0582: Experience with Multiple Doses

, 1977
Summary.-The hypoxic cell radiosensitizer, Ro 07-0582, has now been given in multiple doses to 16 patients. They have received a total of 15-51 g in 3-20 doses.
S. Dische, I. R. Flockhartt, G. E. Adamst, M. I. Saunders, M. E. Lee   +4 more
core  

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma

, 2020
The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or ...
Ju Yeon Oh, Jae Kuk Yoo, Eun Ho Kim, Youn Kyoung Jeong, Sun Ha Lim   +4 more
core   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

In vitro Analyse von superparamagnetischen Eisenoxidnanopartikeln als Radiosensitizer für HNSCC-Zellen [PDF]

Superparamagnetische Eisenoxid-Nanopartikel (SPIONs) mit einer Beschichtung aus (3-Aminopropyl) -Triethoxysilan (APTES) eignen sich sehr gut zur medizinischen Anwendung: Wie alle SPIONs sind sie durch ein Magnetfeld steuerbar und können aktiv im Körper ...
Emer, Clara
core   +1 more source

Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2001
Phenylbutyrate (PB) is a histone deacetylase inhibitor that has been shown to induce differentiation and apoptosis in various cancer cell lines. Although these effects are most likely due to modulation of gene expression, the specific genes and gene ...
Meidee Goh, Feng Chen, Michelle T. Paulsen, Ann M. Yeager, Erica S. Dyer, Mats Ljungman   +5 more
doaj   +1 more source