Results 91 to 100 of about 9,097 (242)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

The Choice Between Definitive Radiotherapy and Surgery for Cervical Cancer With Different Histology in Current Clinical Practice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT For cervical cancer, the choice between definitive radiotherapy (RT) and surgery has long been a topic of debate. Clinical factors, including histology and tumor burden, have been examined in prior studies. Given recent advances in RT and the incorporation of concurrent chemotherapy, our study seeks to assess the optimal treatment modality for
Yu‐Lun Wu, Chen‐Wei Ho, Wen‐Shiung Liou, Chun‐Hao Yin, Jin‐Shuen Chen, Yao‐Shen Chen, Yu‐Wei Lin, Ju‐Chun Chien   +7 more
wiley   +1 more source

Electron Attachment Studies with the Potential Radiosensitizer 2-Nitrofuran

, 2020
Nitrofurans belong to the class of drugs typically used as antibiotics or antimicrobials. The defining structural component is a furan ring with a nitro group attached. In the present investigation, electron attachment to 2-nitrofuran (C4H3NO3), which is
Milan Ončák, Eugene Arthur-Baidoo, Stephan Denifl, Muhammad Saqib   +3 more
core   +1 more source

A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer [PDF]

, 2016
Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term side effects. Since radiotherapy
Würdinger, Tom, Kaspers, Gertjan J.L., Hiddingh, Lotte, Cloos, Jacqueline, Kogiso, Mari, Noske, David P., Lagerweij, Tonny, Crommentuijn, Matheus H.W., Tannous, Bakhos, Vandertop, W. Peter, Biesmans, Dennis, Hulleman, Esther, Li, Xiao-Nan   +12 more
core   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons [PDF]

, 2019
Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage.
Feketeová, Linda, Denifl, Stephan, Rebecca Meißner, Eugen Illenberger, Illenberger, Eugen, Linda Feketeová, Meiβner, Rebecca, Stephan Denifl, Meißner, Rebecca   +8 more
core   +1 more source

Ultrasound-stimulated Microbubbles for Treatment of Pancreatic Cancer Cells with Radiation and Nanoparticles: In vitro Study

Journal of Medical Physics
Purpose: This study aims to investigate the radiation enhancement effects of ultrasound-stimulated microbubbles (USMB) with X-rays and nanoparticles on pancreatic cancer cells in vitro.
Masao Nakayama, Ayaha Noda, Hiroaki Akasaka, Takahiro Tominaga, Giulia McCorkell, Moshi Geso, Ryohei Sasaki   +6 more
doaj   +1 more source

A review of preoperative chemoradiotherapy for lower rectal cancer

Journal of the Anus, Rectum and Colon, 2017
In Western countries, rectal cancer has been treated by chemoradiotherapy (CRT) for several decades now, and good local control has been reported. However, Japanese guidelines did not strongly recommend CRT, because CRT is only useful for achieving local
Naohito Beppu, Hidenori Yanagi, Naohiro Tomita   +2 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Shell-dependent photofragmentation dynamics of a heavy-atom-containing bifunctional nitroimidazole radiosensitizer

Radiation therapy uses ionizing radiation to break chemical bonds in cancer cells, thereby causing DNA damage and leading to cell death. The therapeutic effectiveness can be further increased by making the tumor cells more sensitive to radiation.
Caleman, Carl,, De Santis, Emiliano, Kooser, Kuno,, Caleman, Carl, Pihlava, Lassi,, Käämbre, Tanel,, Akiyama, Tomoko, Björneholm, Olle, De Santis, Emiliano,, Svensson, Pamela,, Berholts, Marta,, Hessenthaler, Lisa,, Björneholm, Olle,, Berholts, Marta, Pihlava, Lassi, Giehr, Flavia, André, Tomas,, Akiyama, Tomoko,, Käämbre, Tanel, Tonisoo, Arvo,, Kukk, Edwin, Tonisoo, Arvo, Svensson, Pamela, Giehr, Flavia,, Hessenthaler, Lisa, Kooser, Kuno, Kukk, Edwin,, André, Tomas   +27 more
core   +1 more source