Results 101 to 110 of about 164,482 (307)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Adjuvant Intra-Arterial Chemotherapy and Radiotherapy Versus Surgery Alone in Resectable Pancreatic and Periampullary Cancer A Prospective Randomized Controlled Trial

, 2008
Background: Success of surgical treatment for pancreatic and periampullary cancer is often limited due to locoregional recurrence and/or the development of distant metastases. Objective: The survival benefit of celiac axis infusion (CAI) and radiotherapy
van Eijck, Casper, Hop, Wim C.J., Morak, Marjolein, Kazemier, G, Incrocci, Luca; id_orcid, van der Gaast, Ate, Jeekel, J (Hans), Hop, Hermans, John, Incrocci, Luca, van Dekken, H (Herman)   +10 more
core   +1 more source

Adjuvant radiotherapy for DCIS

The Lancet, 2000
Jeremy Millar, Alan Rodger
  +6 more sources

Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

Balkan Medical Journal, 2016
Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly.
İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdoğan, M. Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç, Mehmet Atilla Uysal, Sinem İliaz   +22 more
doaj   +1 more source

Role of Adjuvant Radiotherapy in Gastric Cancer

Journal of Gastric Cancer, 2023
Although continuous improvement in the treatment outcome of localized gastric cancer has been achieved through early screening, diagnosis, and treatment and the active application of surgery and adjuvant chemotherapy, the necessity of adjuvant radiotherapy (RT) remains controversial.
openaire   +2 more sources

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Postoperative Radiotherapy after Radical Prostatectomy: Indications and Open Questions

Prostate Cancer, 2012
Biochemical relapse after radical prostatectomy occurs in approximately 15–40% of patients within 5 years. Postoperative radiotherapy is the only curative treatment for these patients. After radical prostatectomy, two different strategies can be offered,
Pirus Ghadjar, Daniel Zwahlen, Daniel M. Aebersold, F. Zimmermann   +3 more
doaj   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Primary mucosal sinonasal melanoma—Case report and review of the literature. The role of complex treatment-surgery and adjuvant radiotherapy

, 2011
AimThe place of adjuvant radiotherapy in the treatment of sinonasal melanoma.BackgroundSinonasal mucosal melanoma is a rare disease with poor prognosis and requires a complex treatment.
Yordanov, Kaloyan; Radiotherapy Department, Oncology Hospital, Medical University – Varna, Varna, Bulgaria, Marinova, Lena; Radiotherapy Department, Oncology Hospital, Medical University – Varna, Varna, Bulgaria, Sapundgiev, Nikolay; Oto-rhyno-laryngology Department, University Hospital “Sveta Marina”, Medical University – Varna, Varna, Bulgaria   +2 more
core   +1 more source

Distribution of oral carcinoma case requiring radiotherapy in the Oral and Maxillofacial Surgery Clinics

Padjadjaran Journal of Dentistry, 2015
Introduction: Carcinoma is a highly malignant tumour of epithelium that occurred in the oral cavity. One of the most common therapies given is radiotherapy, with healing, adjuvant, and palliative intentions.
Dinda Tegar Jelita, Lucky Riawan, Herman Hambali   +2 more
doaj   +1 more source