Results 111 to 120 of about 227,291 (309)

Comparison of adjuvant versus salvage radiotherapy policies for postprostatectomy radiotherapy

International Journal of Radiation Oncology*Biology*Physics, 2004
We compared the long-term results of postprostatectomy radiotherapy (RT) from two institutions, one adapting a prospective policy of adjuvant RT and the other salvage RT.Between 1989 and 1997, 69 patients were referred for adjuvant RT to the institution using adjuvant RT and 88 patients with evidence of recurrence were treated in the institution using ...
Department of Radiation Oncology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA ( host institution ), Hagan, Michael ( author ), Zlotecki, Robert ( author ), Medina, Camillo ( author ), Tercilla, Oscar ( author ), Rivera, Inoel ( author ), Wajsman, Zev ( author )   +6 more
openaire   +3 more sources

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Outcome of high grade gliomas–An institutional experience

Acta Medica International, 2017
Objective: In this study we evaluated the prognostic factors, dosimetry and survival outcome of high grade gliomas receiving radiotherapy with concurrent temozolomide and with or without adjuvant temozolomide.
Nagarjuna Burela, Nidhi Patni
doaj   +1 more source

The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer [PDF]

, 2008
The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited.
A Ciucci, A Lannigan, A-M McNicol, AHS Lee, AHS Lee, AM Al Murri, AM Al Murri, AM Al Murri, AM McNicol, B Uzzan, C Badoual, C O'Sullivan, C Wilson, CD Griffith, CG Lis, D C McMillan, DC McMillan, DC McMillan, DC McMillan, EJ Bromwich, EY Lin, G Zhang, H Trihia, HM Ogmundsdottir, HO Wintzer, I Laursen, J Bell, J C Doughty, J Galon, J Vakkila, JA Anderson, JA Soreide, JL Yu, K Canna, KV Albuquerque, LM Coussens, LM Forrest, M Hilmy, M Retsky, M Toi, MC Haffner, MP Margarson, N Jonjic, P Goldwasser, P Reizenstein, PA McArdle, RD Leek, S Hansen, S Hansen, S Tsutsui, S Vgenopoulou, SM Pupa, SM Veronese, T Scholzen, TH Stewart, V Carstairs, Y Zhou   +56 more
core   +2 more sources

Adjuvant Radiotherapy in Breast Cancer [PDF]

Breast Care, 2006
Locoregional external beam radiation therapy using linear accelerators is an essential component of a multimodal treatment concept with a curative intent after primary surgical therapy in non-invasive and locally confined invasive breast cancer. Its important role has been confirmed at the highest level of evidence by recent results of prospective ...
openaire   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Whole breast and regional nodal irradiation in prone versus supine position in left sided breast cancer [PDF]

, 2017
Background: Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole breast + lymph node irradiation (WB +
A Berrington de Gonzalez, AM Kirby, Annick Van Greveling, Bert Boute, Bruno Speleers, BT Gielda, BV Offersen, BV Offersen, Chris Monten, CR Jephcott, FR Bartlett, FR Bartlett, G Alco, Giselle Post, Herman Depypere, I Finke, IR Vogelius, IY Jo, J Buijsen, J Reznik, JD Boice Jr, Joris Van de Velde, K Kainz, K Verhoeven, K Verhoeven, L Veldeman, LB Marks, LB Thorsen, Leen Paelinck, Liv Veldeman, LM Sun, M Alonso-Basanta, M Feng, M Stovall, N Dogan, N Mason, P McGale, PD Inskip, Pieter Deseyne, PM Poortmans, RA Sethi, SC Darby, SC Formenti, SC Lymberis, SM Shin, T Grantzau, T Grantzau, T Mulliez, T Mulliez, T Mulliez, T Mulliez, T Viren, TE Merchant, TJ Whelan, Tom Van Hoof, Wilfried De Neve, X Gao   +56 more
core   +2 more sources

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Multimodal treatment for local recurrent malignant gliomas: resurgery and/or reirradiation followed by chemotherapy [PDF]

, 2019
The therapeutic management of recurrent malignant gliomas (MGs) is not determined. Therefore, the efficacy of a multimodal approach and a combination systemic therapy was investigated.
Bianco, Vincenzo, ELENA REBUZZI, Sara, Ferrara, Carla, Fusto, Carmela, GIRON BERRIOS, JULIO RODRIGO, Grassi, Massimiliano, Pecorari, Silvia, Prelaj, Arsela, Salvati, Maurizio, Stati, Valeria, Tomao, Silverio   +10 more
core   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source