Results 51 to 60 of about 164,482 (307)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The impact of adjuvant therapies on patient survival and the recurrence patterns for resected stage IIa–IVa lower thoracic oesophageal squamous cell carcinoma

World Journal of Surgical Oncology, 2018
Background This study evaluated the impact of adjuvant therapies on patient survival and disease recurrence patterns to identify an effective adjuvant therapy for resected lower thoracic oesophageal squamous cell carcinoma (LTESCC). Methods Clinical data
Yichun Wang, Liyang Zhu, Wanli Xia, Liming Wu, Fan Wang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas [PDF]

, 2017
Purpose: The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus ...
Gambarotti, Marco, Silvia Cammelli, Ferrari, Stefano, Gian Carlo Mattiucci, Alessandra Arcelli, Cilla, Savino, Morganti, Alessio Giuseppe, Valentini, Vincenzo, Galuppi, Andrea, Marco Gambarotti, Macchia, Gabriella, Francesco Deodato, Alberto Righi, Stefano Ferrari, Alessio Giuseppe Morganti, Frakulli, Rezarta, Ferraro, Andrea, Cortesi, Annalisa, Buwenge, Milly, Andrea Ferraro, Giuseppe Bianchi, Fabrizio Romani, Davide Donati, Farioli, Andrea, Righi, Alberto, Deodato, Francesco, Savino Cilla, Annalisa Cortesi, Romani, Fabrizio, Andrea Farioli, Bianchi, Giuseppe, Gabriella Macchia, Milly Buwenge, Vincenzo Valentini, Cammelli, Silvia, Andrea Galuppi, Arcelli, Alessandra, Donati, Davide, Rezarta Frakulli, Mattiucci, Gian Carlo   +39 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Prognostic role of adjuvant radiotherapy in triple-negative breast cancer: A historical cohort study

, 2015
The value of adjuvant radiotherapy in triple-negative breast cancer (TNBC) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian women with TNBC.
Hartman, Mikael, Nur Aishah Taib, Nei, Wen-Long, Tan, Ern-Yu, Taib, NA, Verkooijen, Helena M., Jean‐Philippe Pignol, Gwo‐Fuang Ho, Yip, Cheng-Har, Tan, B, Ho, Gwo-Fuang, Cheng‐Har Yip, Wen‐Long Nei, Dent, R, Bhoo-Pathy, N, Kwong, A, Wong, Fuh-Yong, Chan, Patrick, Lee, Soo-Chin, Benita Tan, Tan, EY, Bhoo Pathy, Nirmala, Nei, WL, Hartman, M, Tan, Benita, Mikael Hartman, Lee, SC, Chan, P, Taib, Nur Aishah, Yip, CH, Soo‐Chin Lee, Ava Kwong, Dent, Rebecca, Nirmala Bhoo‐Pathy, Wong, FY, Ho, GF, Patrick Chan, Rebecca Dent, Fuh‐Yong Wong, Ern‐Yu Tan, Kwong, Ava, Verkooijen, HM, Pignol, Jean-Philippe, Helena M. Verkooijen   +43 more
core   +1 more source

Adjuvant Radiotherapy after Surgical Excision in Keloids

, 2021
Keloids are a benign fibroproliferative disease with a high tendency of recurrence. Keloids cause functional impairment, disfigurement, pruritus, and low quality of life. Many therapeutic options have been used for keloids.
Ki Ho Seol, Jeong Won Lee
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Delineation of the Prostate Bed: The “Invisible Target” Is Still an Issue?

Frontiers in Oncology, 2017
For pathological high-risk prostate cancer, adjuvant irradiation has shown a survival benefit. Phase III studies have highlighted that half men would face biochemical relapse and would be candidate for radiotherapy at adjuvant or salvage times.
Igor Latorzeff, Paul Sargos, Geneviève Loos, Stéphane Supiot, Stéphane Guerif, Christian Carrie   +5 more
doaj   +1 more source

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue [PDF]

, 2014
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets.
Philip John Coates, Torben Wilms, Laurell, Göran,, Rentoft, Matilda,, Coates, Philip John, Matilda Rentoft, Lotta Loljung, Göran Laurell, Karin Nylander, Rentoft, Matilda, Laurell, Göran, Wilms, Torben, Loljung, Lotta, Nylander, Karin, Loljung, Lotta,, Wilms, Torben,, Nylander, Karin,, Coates, Philip John,   +17 more
core   +1 more source