Results 71 to 80 of about 829,320 (360)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Image-guided high-dose-rate brachytherapy: preliminary outcomes and toxicity of a joint interventional radiology and radiation oncology technique for achieving local control in challenging cases. [PDF]

, 2015
PurposeTo determine the ability of image-guided high-dose-rate brachytherapy (IG-HDR) to provide local control (LC) of lesions in non-traditional locations for patients with heavily pre-treated malignancies.Material and methodsThis retrospective series ...
Demanes, D Jeffrey, Genshaft, Scott, Hagio, Mary Ann, Kamrava, Mitchell, Kishan, Amar U, Lee, Edward W, Lu, David, McWilliams, Justin, Motamedi, Kambiz, Park, Sang June, Wang, Pin-Chieh   +10 more
core   +2 more sources

De-intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV-positive oropharyngeal carcinoma.

Cochrane Database of Systematic Reviews, 2018
BACKGROUND More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV).
James E F Howard, Raghav C Dwivedi, L. Masterson, P. Kothari, H. Quon, F. C. Holsinger   +5 more
semanticscholar   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

The impact of loco-regional recurrences on metastatic progression in early-stage breast cancer: a multistate model [PDF]

, 2009
To study whether the effects of prognostic factors associated with the occurrence of distant metastases (DM) at primary diagnosis change after the incidence of loco-regional recurrences (LRR) among women treated for invasive stage I or II breast cancer ...
A Fourquet, AC Voogd, B Fisher, B Fisher, B Fisher, C Vrieling, C. J. van de Velde, D Cowen, E Touboul, Early Breast Cancer Trialists’ Collaborative Group, G Coulombe, G. H. de Bock, H Bartelink, H Kemperman, H Putter, H. Bartelink, H. Putter, HM Nielsen, I Soerjomataram, J Dongen Van, J Engel, J Hage Van der, J Hage Van der, J Ragaz, J. A. van der Hage, J. Bonnema, JA Dongen Van, JA Dongen Van, JG Nes Van, L Livi, M Clarke, M Leest Van der, M Sangen Van der, MA Bollet, N Kroman, P Broet, PC Clahsen, PH Elkhuizen, PH Elkhuizen, R Arriagada, R Arriagada, RS Punglia, U Veronesi, WS Halsted   +43 more
core   +3 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Salvage versus adjuvant radiotherapy after radical prostatectomy: argument for adjuvant radiotherapy [PDF]

Canadian Urological Association Journal, 2013

openaire   +2 more sources

Adjuvant radiotherapy and chemotherapy in breast cancer [PDF]

Journal of British Surgery, 1986
Abstract Three hundred and twenty-two women with involvement of axillary lymph nodes following surgery for operable breast cancer were randomized to receive either postoperative radiotherapy, chemotherapy (CMF) or radiotherapy followed by chemotherapy.
C. S. McArdle, D. C. Smith, D. Crawford, K. C. Calman, David J Hole, A. R. Russell, E. H. Dykes   +6 more
openaire   +2 more sources

Close Margins and Adjuvant Radiotherapy in Acinic Cell Carcinoma of the Parotid Gland

JAMA Otolaryngology - Head and Neck Surgery, 2018
Importance The precise indications and oncologic effects of adjuvant radiotherapy in acinic cell carcinoma of the parotid gland are not well known, particularly in patients with negative, but close (⩽1 mm), margins without other high-risk histopathologic
J. Zenga, A. S. Parikh, K. Emerick, D. Lin, W. Faquin, D. Deschler   +5 more
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source