Results 151 to 160 of about 42,443 (305)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Nordic Society of Paediatric Haematology and Oncology (NOPHO) Radiotherapy Working Group consensus guidelines on radiotherapy for paediatric low-grade gliomas. [PDF]

Acta Oncol
Embring A, Skyttä T, Engellau J, Kerna I, Sendiuliene D, Blomstrand M, Indelicato DJ, Timmermann B, Lassen-Ramshad Y, Magelssen H.   +9 more
europepmc   +1 more source

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

Three-dimensional Conformal Radiation Planning Study for Limited-stage Small-cell Lung Cancer. [PDF]

Cancer Diagn Progn
Okada Y, Zama T, Itonaga T, Mikami R, Okubo M, Sugahara S, Wada S, Kawamoto T, Ishida M, Nakai M, Abe K, Yoshimura M, Kodama T, Kurooka M, Saito K.   +14 more
europepmc   +1 more source

Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma

The Laryngoscope, EarlyView.
Conflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
Adrian L. James
wiley   +1 more source

New approach to treatment planning: Plenary lecture [PDF]

Archive of Oncology, 2002
Suter Bruno
doaj   +1 more source

Automated fluence optimization in breast cancer radiotherapy: balancing dosimetric quality, organ-at-risk sparing, and workflow efficiency. [PDF]

Radiat Oncol
Choi YE, Shin HB, Sung K.
europepmc   +1 more source

Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis

The Laryngoscope, EarlyView.
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua, Yong Hoe Chan, Woei Shyang Loh, De Yun Wang   +3 more
wiley   +1 more source

Advances in Radiation Therapy for Unresectable Locally Advanced Non-Small Cell Lung Cancer: From Technical Advances to Immunotherapy Integration. [PDF]

Juntendo Med J
Murakami N.
europepmc   +1 more source

Novel DCAT plans in stereotactic body radiotherapy for stage I/II centrally located non-small-cell lung cancer. [PDF]

Sci Rep
Huang Y, Yang J, Wang C, Yang J, Hou G, Long C, Liu Y.   +6 more
europepmc   +1 more source