Results 231 to 240 of about 28,886 (305)

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Limited pelvic radiotherapy in post-operative uterine carcinoma. [PDF]

Rep Pract Oncol Radiother
Alexander HN, Udayashankara AH, Johnson S, Srikantia N, Raj JM.   +4 more
europepmc   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Case Report: Complete remission after radiotherapy in two cases of locally advanced extramammary Paget's disease of the perineum. [PDF]

Front Oncol
Ma H, Xie X, Peng X.
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Radiotherapy for Hypopharyngeal Carcinoma: Analysis of Multi-institutional Data From Over 170 Patients. [PDF]

Cureus
Yamazaki H, Suzuki G, Norihiro A, Kimoto T, Masui K, Kawabata K, Nagasawa S, Yoshino Y, Hirano S, Asato A, Ikeda S, Yamada K, Kodani N, Shimizu D.   +13 more
europepmc   +1 more source

Reference Values for Pulse Oximetry Testing in Permanent Teeth: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Pulse oximetry is an accurate diagnostic method for assessing the condition of the dental pulp; however, the normal oxygen saturation levels for each tooth type are yet to be clearly defined. Objectives This systematic review and meta‐analysis aims to answer the question: What are the reference values for pulse oximetry testing in ...
Lilian Tietz, Theodoro Weissheimer, Cassiano Kuchenbecker Rösing, Marcus Vinicius Reis Só   +3 more
wiley   +1 more source

Stereotactic Body Radiotherapy (SBRT) for Liver Tumors: A Systematic Review on the Choice of Photon Energy and Linac Flattened/Unflattened Beams. [PDF]

Cureus
Adavikolanu KR, R C, Kaliyath SB, M T, K S AR, Kari ND, Neerudu P, Yadala A, Palla M, Kondeti AK.   +9 more
europepmc   +1 more source

Non‐Pharmacological Interventions for Cough in Patients With Lung Cancer: A Systematic Review and Meta‐Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Cough, a prevalent and debilitating symptom of lung cancer, remains poorly managed. Accumulating evidence on non‐pharmacological interventions for lung cancer cough necessitates systematic evaluation to assess their efficacy. Aim To synthesise evidence on non‐pharmacological interventions for managing cough in lung cancer patients ...
Mengyao Cao, Xueyan Cheng, Victor Ho‐fun Lee, Chia‐Chin Lin, Denise Shuk Ting Cheung   +4 more
wiley   +1 more source