Results 111 to 120 of about 1,908,615 (320)

Compact dose delivery of laser-accelerated high-energy electron beams toward radiotherapy applications

Physical Review Accelerators and Beams
The use of very high-energy electron (VHEE) beams for radiotherapy has been actively studied for over two decades due to their advantageous dose distribution, deep penetration depth, and great potential of ultrahigh dose-rate irradiation. Recently, laser-
Bing Zhou, Zhiyuan Guo, Yang Wan, Shuang Liu, Bo Peng, Jianfei Hua, Wei Lu   +6 more
doaj   +1 more source

Impact of Metallic Implants on Dose Distribution in Radiotherapy with Electrons, Photons, Protons, and Very-High-Energy Beams

Applied Sciences
Metallic implants in radiotherapy patients alter dose distributions due to their high density and unique composition, potentially compromising treatment precision.
Nicole Kmec Bedri, Milan Smetana, Ladislav Janousek   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dosimetric characterization of the laser-accelerated high-energy electron beam for radiotherapy applications

Physical Review Accelerators and Beams
Radiotherapy utilizing very-high-energy electron (VHEE) beams in the range of 50–300 MeV has gained significant interest over the past two decades due to their advantageous dose characteristics, deep tissue penetration capabilities, and potential for ...
Bing Zhou, Zhiyuan Guo, Shuang Liu, Yang Wan, Junqi Liu, Haiyang Wang, Yifei Pi, Bo Guo, Jianfei Hua, Wei Lu   +9 more
doaj   +1 more source

Radiotherapy for Rectal Cancer and Radiation-Induced Malignancies from Epidemiological and Dosimetric Data

Applied Sciences
Preoperative or postoperative radiation therapy is broadly employed in patients with rectal carcinoma. Radiotherapy directs high-energy beams of ionizing radiation toward the tumor area to destroy cancer cells.
Stefanos Kachris, Michalis Mazonakis
doaj   +1 more source

Single institution implementation of permanent 131Cs interstitial brachytherapy for previously irradiated patients with resectable recurrent head and neck carcinoma [PDF]

, 2019
Purpose: Permanent interstitial brachytherapy is an appealing treatment modality for patients with locoregional recurrent, resectable head and neck carcinoma (HNC), having previously received radiation.
Bar-Ad, Voichita, Cognetti, David, Curry, Joseph, Doyle, Laura, Harrison, Amy, Hubley, Emily, Johnson, Jennifer, Keller, James, Luginbuhl, Adam, Peng, Cheng, To, David   +10 more
core   +1 more source

Deterministic Partial Differential Equation Model for Dose Calculation in Electron Radiotherapy

, 2009
Treatment with high energy ionizing radiation is one of the main methods in modern cancer therapy that is in clinical use. During the last decades, two main approaches to dose calculation were used, Monte Carlo simulations and semi-empirical models based
B Dubroca, Börgers C, Coulombel J-F, Davison B, Dubroca B, Dubroca B, Gifford K A, Hensel H, Krieger T, Lehmann C, M Frank, Mihalas D, Modest M F, Mott N F, Müller I, R Duclous, Salvat F, Tervo J, Vassiliev O N, Zerby C D   +19 more
core   +1 more source

Radiation dose to radiotherapy technologists due to induced activity in high energy medical electron linear accelerators

, 2014
After delivering X-ray beam of 15 MV energy, measurable radiation level near the treatment head of medical electron linear accelerator (LINAC) and in its surrounding is observed due to induced activity generated in target, flattening filter, monitor ...
O. Gurjar, V. Jha, S. Sharma
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source