International Journal of Cancer, EarlyView.Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger +13 more
wiley +1 more source
Targeting glutathione metabolism for tumor radiosensitization (Review). [PDF]
Int J Mol MedXu H, Du M, Liang X, Xiao X, Chen Z.
europepmc +1 more source
International Journal of Cancer, EarlyView.Associations between outdoor air pollution and cancers other than lung cancer remain unclear, particularly in the context of tobacco use. Here, the authors assessed possible links between ambient air pollutant exposure and incidence of 20 non‐lung cancers among adults followed over a 25‐year period in the United States.
W. Ryan Diver +4 more
wiley +1 more source
Radiosensitisation of Head and Neck Cancer Cells to Protons of Increasing LET Through Targeting DNA Double Strand Break Repair. [PDF]
CellsDufficy ER +4 more
europepmc +1 more source
International Journal of Cancer, EarlyView.The therapeutic status of drug administration in phase 2 cancer trials is ambiguous, as these studies test efficacy without strong evidence of clinical benefit. Nonetheless, patients face meaningful risks. This review compared efficacy and safety of monotherapy drugs in phase 2 and phase 3 trials across six cancer types.
Charlotte Ouimet +2 more
wiley +1 more source
A beam model and Boltzmann solver for radiotherapy treatment planning of superficial brain metastases using a scanned electron beam at ultra-high (FLASH) dose rate. [PDF]
Phys Med BiolBedford J +5 more
europepmc +1 more source
Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time‐Varying Relationship
International Journal of Cancer, EarlyView.Experimental studies in animals suggest that oxidative stress (OxS) declines as cancer progresses. Whether this occurs in humans, however, remains unclear. The authors of the present study addressed this question by analyzing lipid, DNA, and RNA oxidation biomarkers in relation to colorectal cancer (CRC) risk in patients from Shanghai and the United ...
Gong Yang +8 more
wiley +1 more source
Nanomaterials reshaping cancer radiotherapy: Radiosensitization mechanisms, delivery and theranostic platforms, multimodal synergy, and clinical translation strategies. [PDF]
Mater Today BioLiu J +5 more
europepmc +1 more source
Hypervision Proton Surgery: The Future Direction of Proton Therapy
iNew Medicine, EarlyView.ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley +1 more source
Radiotherapy in Patients with Cardiac Implantable Devices: A Single-Centre Retrospective Observational Analysis of Local Guidelines. [PDF]
J Clin MedSaghie E +5 more
europepmc +1 more source