Results 21 to 30 of about 72,896 (217)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Monte Carlo study of radiation dose enhancement by gadolinium in megavoltage and high dose rate radiotherapy. [PDF]

PLoS ONE, 2014
MRI is often used in tumor localization for radiotherapy treatment planning, with gadolinium (Gd)-containing materials often introduced as a contrast agent. Motexafin gadolinium is a novel radiosensitizer currently being studied in clinical trials.
Daniel G Zhang, Vladimir Feygelman, Eduardo G Moros, Kujtim Latifi, Geoffrey G Zhang   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Diamond Detectors for Radiotherapy X-Ray Small Beam Dosimetry

Frontiers in Physics, 2021
Many new X-Ray treatment machines using small and/or non-standard radiation fields, e.g., Tomotherapy, Cyber-knife, and linear accelerators equipped with high-resolution multi-leaf collimators and on-board imaging system, have been introduced in the ...
C. Talamonti, C. Talamonti, K. Kanxheri, S. Pallotta, S. Pallotta, L. Servoli   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Radiotherapy and creation of safety feeling

نشریه پرستاری ایران, 1999
Radiotherapy is one of the most common treatments of cancer that are used alone or with the combination of other treatments. Radiotherapy are used before surgery for tumor shrinking, pain relief, wound healing or prevention of continues bleedings.
Ordoubadinia, Z
doaj  

MedLinac2: a GEANT4 based software package for radiotherapy

Annali dell'Istituto Superiore di Sanità, 2010
Dose distribution evaluation in oncological radiotherapy treatments is an outstanding problem that requires sophisticated computing technologies to optimize the clinical results (i.e.
Barbara Caccia, Claudio Andenna, Giuseppe Antonio Pablo Cirrone   +2 more
doaj   +1 more source

Monte Carlo calculation of shielding properties of newly developed heavy concretes for megavoltage photon beam spectra used in radiation therapy [PDF]

Iranian Journal of Medical Physics, 2016
Introduction: Globally, the need for radiotherapy as a part of cancer management increases every year. Thus, the shielding for megavoltage radiotherapy rooms is of great importance. Materials and Methods: In the present study, 14 types of developed high-
Rezvan Khaldari, Asghar Mesbahi, Umit Kara   +2 more
doaj   +1 more source

Feasibility study of CdZnTe and CdZnTeSe based high energy X-ray detector using linear accelerator

Nuclear Engineering and Technology, 2023
CdZnTeSe (CZTS) has attracted attention for applications in X- and gamma-ray detectors owing to its improved properties compared to those of CdZnTe (CZT).
Beomjun Park, Juyoung Ko, Jangwon Byun, Byungdo Park, Man-Jong Lee, Jeongho Kim   +5 more
doaj   +1 more source