Results 51 to 60 of about 128,967 (306)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeting the organelle for radiosensitization in cancer radiotherapy

Asian Journal of Pharmaceutical Sciences
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to ...
Xiaoyan Sun, Linjie Wu, Lina Du, Wenhong Xu, Min Han   +4 more
doaj   +1 more source

New approach to evaluate the exit dose quality for high radioprotection and radiotherapy efficiency [PDF]

Ядерна фізика та енергетика, 2018
For safety and radioprotection reasons in radiotherapy treatment, the exit dose is evaluated with irradiation field size and photon beam energy. The objective of this study is to introduce an empirical law for predicting the delivered dose at the other ...
Mohamed Bencheikh, Abdelmajid Maghnouj, Jaouad Tajmouati, Abdessamad Didi, Abdesslam Lamrabet, Yassine Benkhouya   +5 more
doaj   +1 more source

In vivo neutron dosimetry during high-energy Bremsstrahlung radiotherapy

International Journal of Radiation Oncology*Biology*Physics, 1998
A new technique is presented for in vivo measurements of the dose equivalent from photoneutrons produced by high-energy radiotherapy accelerators.The dosimeters used for this purpose are vials of superheated halocarbon droplets suspended in a tissue-equivalent gel.
F, D'Errico, R, Nath, G, Silvano, L, Tana   +3 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

Journal of Biomedical Physics and Engineering, 2019
Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy.
Farahani S., Riyahi Alam N., Haghgoo S., Khoobi M., Geraily Gh., Gorji E.   +5 more
doaj  

Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype

Nature Communications
Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and easy manipulation by magnetic components.
Zhiyuan Guo, Shuang Liu, Bing Zhou, Junqi Liu, Haiyang Wang, Yifei Pi, Xiaoyan Wang, Yingyi Mo, Bo Guo, Jianfei Hua, Yang Wan, Wei Lu   +11 more
doaj   +1 more source

The Measurement of Neutron Contamination in High Energy X-Ray Radiotherapy Using a He-3 Gas Dosimeter [PDF]

Iranian Journal of Medical Physics
Introduction: Neutron contamination is likely caused by the collision of high-energy photon interactions (γ, ṉ) with heavy metals used in the construction of the accelerator.
Alireza Vejdani, Mehdi Momennezhad, Sara Mohammadi, Vajiheh Vejdani Noghreiyan, Atefeh Rostami   +4 more
doaj   +1 more source

The effect and stability of MVCT images on adaptive TomoTherapy. [PDF]

, 2010
Use of helical TomoTherapy-based MVCT imaging for adaptive planning is becoming increasingly popular. Treatment planning and dose calculations based on MVCT require an image value to electron density calibration to remain stable over the course of ...
Paliwal, Bhudatt R, Rong, Yi, Tolakanahalli, Ranjini, Yadav, Poonam   +3 more
core   +1 more source