Results 61 to 70 of about 69,888 (277)

Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation

Frontiers in Immunology, 2022
IntroductionIn situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate tumors either by ...
Renske J. E. van den Bijgaart, Vera E. Mekers, Fabian Schuurmans, Tonke K. Raaijmakers, Melissa Wassink, Andor Veltien, Erik Dumont, Arend Heerschap, Jurgen J. Fütterer, Jurgen J. Fütterer, Gosse J. Adema   +10 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for ...
HE Jun, ZHANG Chengda, JIA Lin, HAN Jianjun, GAO Fei, WANG Yun, JIA Li, JIA Dong, CHEN Yan   +8 more
doaj   +1 more source

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics [PDF]

, 2015
MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice.
Albisinni, Ugo, Battista, Giuseppe, Bazzocchi, Alberto, CATALANO, Carlo, Guglielmi, Giuseppe, NAPOLI, ALESSANDRO, SACCONI, BEATRICE   +6 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. [PDF]

, 2015
The purpose of this study was to evaluate the performance of a commercially available CyberKnife system with a multileaf collimator (CK-MLC) for stereotactic body radiotherapy (SBRT) and standard fractionated intensity-modulated radiotherapy (IMRT ...
Descovich, Martina, Gottschalk, Alexander R, Lessard, Etienne, McGuinness, Christopher M, Nakamura, Jean L, Pinnaduwage, Dilini, Pouliot, Jean, Sims, Colin   +7 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Effect of variations in atelectasis on tumor displacement during radiation therapy for locally advanced lung cancer [PDF]

, 2017
Purpose Atelectasis (AT), or collapsed lung, is frequently associated with central lung tumors. We investigated the variation of atelectasis volumes during radiation therapy and analyzed the effect of AT volume changes on the reproducibility of the ...
Tennyson, Nathan, Weiss, Elisabeth, Sleeman, William, Rosu, Mihaela, Jan, Nuzhat, Hugo, Geoffrey D.   +5 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

GPU-based ultra-fast direct aperture optimization for online adaptive radiation therapy

, 2010
Online adaptive radiation therapy (ART) has great promise to significantly reduce normal tissue toxicity and/or improve tumor control through real-time treatment adaptations based on the current patient anatomy.
Bazaraa M, Bentley J, Chunhua Men, Earl M A, Fox C, Gu X, Gu X, Hoberock J Bell N, Kokubo M, Langen K M, Li M, Li Y J, Men C, Men C, Steve B Jiang, Wong J R, Wu C, Wu Q J, Xing M Decaudin P Baogang H Xiaopeng Z, Xun Jia, Yan D, Zhang G W   +21 more
core   +1 more source